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seip-1 Seipin [ Caenorhabditis elegans ]

Gene ID: 259621, updated on 4-Jan-2025

Summary

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Official Symbol
seip-1
Official Full Name
Seipin
Primary source
WormBase:WBGene00019808
Locus tag
CELE_R01B10.6
See related
AllianceGenome:WB:WBGene00019808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in lipid droplet organization and lipid storage. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Used to study lipodystrophy. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 13; congenital generalized lipodystrophy type 2; hereditary spastic paraplegia; hereditary spastic paraplegia 17; and lipodystrophy. Orthologous to human BSCL2 (BSCL2 lipid droplet biogenesis associated, seipin). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See seip-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (6051377..6053238, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Cystatin cpi-2 Neighboring gene Solute carrier family 3 member 2 N-terminal domain-containing protein Neighboring gene Post-GPI attachment to proteins factor 3 Neighboring gene JNK1/MAPK8-associated membrane protein homolog Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class D (Delta)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Accelerated epigenetic aging and DNA methylation alterations in Berardinelli-Seip congenital lipodystrophy. Qannan A, et al. Hum Mol Genet, 2023 May 18. PMID 36715159, Free PMC Article
  2. Loss of the seipin gene perturbs eggshell formation in Caenorhabditiselegans. Bai X, et al. Development, 2020 Oct 16. PMID 32820022, Free PMC Article
  3. Identification of genetic suppressors for a BSCL2 lipodystrophy pathogenic variant in Caenorhabditis elegans. Bai X, et al. Dis Model Mech, 2024 Jun 1. PMID 38454882, Free PMC Article
  4. The autophagy protein ATG9A enables lipid mobilization from lipid droplets. Mailler E, et al. Nat Commun, 2021 Nov 19. PMID 34799570, Free PMC Article
  5. Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans. Mosquera JV, et al. PLoS Genet, 2021 Jun. PMID 34133414, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans.
    Title: Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans.
  2. Loss of the seipin gene perturbs eggshell formation in Caenorhabditis elegans.
    Title: Loss of the seipin gene perturbs eggshell formation in Caenorhabditiselegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in lipid droplet formation IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid droplet organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid storage IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Seipin
NP_741547.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6051377..6053238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171465.5 → NP_741547.1  Seipin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741547.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MXG1
    Conserved Domains (1) summary
    pfam06775
    Location:16 → 216
    Seipin; Putative adipose-regulatory protein (Seipin)
Nucleotide Protein
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