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rcs-1 RING-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 259719, updated on 9-Dec-2024

Summary

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Official Symbol
rcs-1
Official Full Name
RING-type domain-containing protein
Primary source
WormBase:WBGene00016190
Locus tag
CELE_C28G1.5
See related
AllianceGenome:WB:WBGene00016190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable zinc ion binding activity. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic cancer (multiple). Orthologous to several human genes including BSPRY (B-box and SPRY domain containing); MEFV (MEFV innate immunity regulator, pyrin); and RNF39 (ring finger protein 39). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rcs-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (8826604..8828540, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene Intermediate filament protein ifd-1 Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene Exocyst complex component 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in Caenorhabditis elegans. Panek J, et al. Proc Natl Acad Sci U S A, 2020 Apr 7. PMID 32193347, Free PMC Article
  2. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
  3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING-type domain-containing protein
NP_001123114.1
  • Confirmed by transcript evidence
NP_001361935.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8826604..8828540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129642.5 → NP_001123114.1  RING-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123114.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WFJ8
    Conserved Domains (2) summary
    cd16516
    Location:5 → 51
    RING-HC_malin; RING finger, HC subclass, found in malin and similar proteins
    cl00034
    Location:94 → 143
    Bbox_SF; B-box-type zinc finger superfamily

  2. NM_001375093.1 → NP_001361935.1  RING-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYH9
    Conserved Domains (1) summary
    cd16516
    Location:5 → 51
    RING-HC_malin; RING finger, HC subclass, found in malin and similar proteins
Nucleotide Protein
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