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TENM4 teneurin transmembrane protein 4 [ Homo sapiens (human) ]

Gene ID: 26011, updated on 27-Nov-2024

Summary

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Official Symbol
TENM4provided by HGNC
Official Full Name
teneurin transmembrane protein 4provided by HGNC
Primary source
HGNC:HGNC:29945
See related
Ensembl:ENSG00000149256 MIM:610084; AllianceGenome:HGNC:29945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Doc4; ETM5; ODZ4; TEN4; TNM4; ten-4; Ten-M4
Summary
The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]
Expression
Biased expression in ovary (RPKM 7.7), thyroid (RPKM 3.2) and 8 other tissues See more
Orthologs
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Genomic context

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See TENM4 in Genome Data Viewer
Location:
11q14.1
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (78652829..79441030, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (78586105..79375273, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (78363874..79152074, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:78316253-78316754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:78316755-78317254 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:78333374-78334573 Neighboring gene RNA, U6 small nuclear 311, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:78362445-78362944 Neighboring gene COP9 signalosome subunit 8 pseudogene 3 Neighboring gene uncharacterized LOC124902724 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:78426174-78427373 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:78513123-78513624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:78600263-78600877 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:78639587-78640454 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:78640455-78641322 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:78684852-78685459 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:78736507-78737151 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:78770726-78771226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:78771227-78771727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:78777731-78778297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:78780794-78781350 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:78798117-78798839 Neighboring gene Sharpr-MPRA regulatory region 11539 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:78902796-78903338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:78973733-78974298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:78981107-78981606 Neighboring gene NANOG hESC enhancer GRCh37_chr11:79047749-79048251 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:79129588-79130787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:79182835-79183401 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:79184647-79185230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:79214125-79214624 Neighboring gene microRNA 708 Neighboring gene microRNA 5579 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:79262907-79264106 Neighboring gene uncharacterized LOC105369405 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:79326940-79328139 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:79386305-79386526 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:79389715-79390549 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:79650639-79651838 Neighboring gene NANOG hESC enhancer GRCh37_chr11:79691931-79692432 Neighboring gene origin recognition complex subunit 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Han family with essential tremor caused by the P421L variant of the TENM4 gene in China. Chi W, et al. Neurol Sci, 2023 Jun. PMID 36689009
  2. The risk variant in ODZ4 for bipolar disorder impacts on amygdala activation during reward processing. Heinrich A, et al. Bipolar Disord, 2013 Jun. PMID 23611537
  3. Teneurin transmembrane protein 4 is not a cause for essential tremor in a Canadian population. Houle G, et al. Mov Disord, 2017 Feb. PMID 28158909
  4. Essential tremor linked TENM4 mutation found in healthy Chinese individuals. Chao YX, et al. Parkinsonism Relat Disord, 2016 Oct. PMID 27569844
  5. Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation. Suzuki N, et al. J Orthop Res, 2014 Jul. PMID 24648313

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Han family with essential tremor caused by the P421L variant of the TENM4 gene in China.
    Title: Han family with essential tremor caused by the P421L variant of the TENM4 gene in China.
  2. This study demonstrated the TENM4 mutation associate with Essential tremor in Chinese.
    Title: Essential tremor linked TENM4 mutation found in healthy Chinese individuals.
  3. TENM4 is not a cause for essential tremor in a Canadian population.
    Title: Teneurin transmembrane protein 4 is not a cause for essential tremor in a Canadian population.
  4. Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor. Mutant proteins mislocalize in oligodendrocyte precursor cells.
    Title: Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor.
  5. the ODZ4 risk variant influences reward processing in the amygdala
    Title: The risk variant in ODZ4 for bipolar disorder impacts on amygdala activation during reward processing.
  6. Ten-4 suppresses chondrogenic differentiation and regulates the expression and activation of the key molecules for chondrogenesis
    Title: Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation.
  7. Data indicate that expression of several predicted chimeric genes and genes with disrupted exon structure including ALK, NBAS, FHIT, PTPRD and ODZ4 in neuroblastoma.
    Title: Breakpoint features of genomic rearrangements in neuroblastoma with unbalanced translocations and chromothripsis.
  8. An intronic variant in ODZ4 is being associated with bipolar disorder.
    Title: Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities.
  10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Tremor, hereditary essential, 5
MedGen: C4225223 OMIM: 616736 GeneReviews: Not available
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EBI GWAS Catalog

Description
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
EBI GWAS Catalog
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
EBI GWAS Catalog
Genome-wide association study of retinopathy in individuals without diabetes.
EBI GWAS Catalog
Genome-wide association study reveals two new risk loci for bipolar disorder.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ99165

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cardiac cell fate specification IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system myelin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system myelin formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in gastrulation with mouth forming second IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
teneurin-4
Names
downstream of CHOP 4
odz, odd Oz/ten-m homolog 4
protein Odd Oz/ten-m homolog 4
tenascin-M4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051803.1 RefSeqGene

    Range
    4622..792823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098816.3 → NP_001092286.2  teneurin-4

    See identical proteins and their annotated locations for NP_001092286.2

    Status: REVIEWED

    Source sequence(s)
    AB037723, AP001838, AP002515, AP002768, AP002957, BX640737, DR000247
    Consensus CDS
    CCDS44688.1
    UniProtKB/Swiss-Prot
    A6ND26, Q6N022, Q7Z3C7, Q96MS6, Q9P2P4, Q9Y4S2
    Related
    ENSP00000278550.7, ENST00000278550.12
    Conserved Domains (10) summary
    COG3209
    Location:1682 → 2474
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1232 → 1271
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1676 → 1716
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2382 → 2461
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:627 → 775
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:11 → 340
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:631 → 657
    EGF_2; EGF-like domain
    pfam15636
    Location:2687 → 2762
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1222 → 1563
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:745 → 786
    DSL; Delta serrate ligand

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    78652829..79441030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426739.1 → XP_047282695.1  teneurin-4 isoform X5

  2. XM_047426737.1 → XP_047282693.1  teneurin-4 isoform X3

  3. XM_047426736.1 → XP_047282692.1  teneurin-4 isoform X2

  4. XM_017017525.2 → XP_016873014.1  teneurin-4 isoform X1

  5. XM_047426742.1 → XP_047282698.1  teneurin-4 isoform X8

  6. XM_047426741.1 → XP_047282697.1  teneurin-4 isoform X7

  7. XM_047426740.1 → XP_047282696.1  teneurin-4 isoform X6

  8. XM_047426738.1 → XP_047282694.1  teneurin-4 isoform X4

  9. XM_011544933.4 → XP_011543235.1  teneurin-4 isoform X9

    Conserved Domains (6) summary
    COG3209
    Location:750 → 1446
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:380 → 419
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:824 → 864
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:1530 → 1609
    Rhs_assc_core; RHS repeat-associated core domain
    pfam15636
    Location:1835 → 1910
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:370 → 711
    NHL; NHL repeat unit of beta-propeller proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    78586105..79375273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368378.1 → XP_054224353.1  teneurin-4 isoform X5

  2. XM_054368377.1 → XP_054224352.1  teneurin-4 isoform X3

  3. XM_054368376.1 → XP_054224351.1  teneurin-4 isoform X2

  4. XM_054368375.1 → XP_054224350.1  teneurin-4 isoform X1

  5. XM_054368374.1 → XP_054224349.1  teneurin-4 isoform X10

  6. XM_054368379.1 → XP_054224354.1  teneurin-4 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6N022.2 GenPept UniProtKB/Swiss-Prot:Q6N022

Gene LinkOut

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