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Ly49i2 Ly49 inhibitory receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 260324, updated on 4-Jan-2025

Summary

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Symbol
Ly49i2provided by RGD
Full Name
Ly49 inhibitory receptor 2provided by RGD
Primary source
RGD:628669
See related
EnsemblRapid:ENSRNOG00000069072 AllianceGenome:RGD:628669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable carbohydrate binding activity. Involved in negative regulation of signal transduction. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 8.7), Testes (RPKM 5.3) and 4 other tissues See more
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Genomic context

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See Ly49i2 in Genome Data Viewer
Location:
4q42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (166156061..166206865, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (164470840..164495461, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (164876252..164901832, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Ly49 inhibitory receptor 3 Neighboring gene killer cell lectin-like receptor 4 Neighboring gene uncharacterized LOC134486850 Neighboring gene killer cell lectin-like receptor, subfamily A, member 4, pseudogene 1 Neighboring gene killer cell lectin-like receptor, subfamily A, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC class Ia molecule (RT1-A1c). Naper C, et al. Eur J Immunol, 2002 Jul. PMID 12115624
  2. Recognition of class I MHC by a rat Ly49 NK cell receptor is dependent on the identity of the P2 anchor amino acid of bound peptide. Ma BJ, et al. J Immunol, 2011 Sep 15. PMID 21841133, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the identity of the P2 peptide anchor residue is an integral component of MHC-I recognition by Ly49i2
    Title: Recognition of class I MHC by a rat Ly49 NK cell receptor is dependent on the identity of the P2 anchor amino acid of bound peptide.
  2. Ly49i2 is an inhibitory natural killer cell receptor for specific MHC class Ia molecule (RT1-A1(c))
    Title: Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC class Ia molecule (RT1-A1c).
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ly49 inhibitory receptor 2; ly49 inhibitory receptor 2
Names
killer cell lectin-like receptor 5-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152848.2 → NP_690061.2  Ly49 inhibitory receptor 2

    Status: VALIDATED

    Source sequence(s)
    AY115572, JAXUCZ010000004
    UniProtKB/TrEMBL
    Q8K3G1
    Related
    ENSRNOP00000068787.3, ENSRNOT00000078690.3
    Conserved Domains (1) summary
    cd03593
    Location:145 → 260
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    166156061..166206865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285636.1 → XP_063141706.1  ly49 inhibitory receptor 2 isoform X2

    UniProtKB/TrEMBL
    A6IM89

  2. XM_063285635.1 → XP_063141705.1  ly49 inhibitory receptor 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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