PRAS40 Proline-rich Akt substrate 40 kDa [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PRAS40provided by FlyBase
Official Full Name: Proline-rich Akt substrate 40 kDaprovided by FlyBase
Primary source: FLYBASE:FBgn0267824
Locus tag: Dmel_CG46146
See related: AllianceGenome:FB:FBgn0267824
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10109; CG46146; Dmel\CG46146; dPRAS40; L
Summary: Involved in negative regulation of TORC1 signaling; negative regulation of insulin receptor signaling pathway; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Located in cytosol. Is expressed in embryonic/larval salivary gland; fat body; gonad; gut; and imaginal disc. Orthologous to human AKT1S1 (AKT1 substrate 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14481187..14497312)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:: NT_033778.4 Chromosome 2R Reference Release 6 plus ISO1 MT Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Process	Evidence Code	Pubs
involved_in negative regulation of TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TOR signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neurotrophin TRK receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain