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CG46280 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 26067077, updated on 27-Dec-2024

Summary

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Official Symbol
CG46280provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0283438
Locus tag
Dmel_CG46280
See related
AllianceGenome:FB:FBgn0283438
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12360; Dmel\CG46280
Summary
Predicted to enable mitochondrion-mitochondrion outer membrane tether activity. Involved in mitochondrial fusion. Is active in mitochondrial outer membrane. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and gut section. Used to study neurodegenerative disease. Orthologous to human TRABD (TraB domain containing). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG46280 in Genome Data Viewer
Location:
87D9-87D9; 3-53 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13026283..13030659, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene C-terminal Binding Protein Neighboring gene uncharacterized protein Neighboring gene lethal (3) 87Df Neighboring gene rosy

Genomic regions, transcripts, and products

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Genomic Sequence:
NT_033777.3 Chromosome 3R Reference Release 6 plus ISO1 MT Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TRABD modulates mitochondrial homeostasis and tissue integrity. Zhou C, et al. Cell Rep, 2024 Jun 25. PMID 38843396
  2. Regulators of autophagosome formation in Drosophila muscles. Zirin J, et al. PLoS Genet, 2015 Feb. PMID 25692684, Free PMC Article
  3. The Drosophila Helicase Maleless (MLE) is Implicated in Functions Distinct From its Role in Dosage Compensation. Cugusi S, et al. Mol Cell Proteomics, 2015 Jun. PMID 25776889, Free PMC Article
  4. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
  5. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mitochondrion-mitochondrion outer membrane tether activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG46280-PA
CG46280-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13026283..13030659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169493.3 → NP_731765.1  uncharacterized protein Dmel_CG46280, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731765.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VG01
    Conserved Domains (1) summary
    cl12050
    Location:251 → 444
    TraB; TraB family

  2. NM_141996.3 → NP_650253.1  uncharacterized protein Dmel_CG46280, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650253.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VG01
    Conserved Domains (1) summary
    cl12050
    Location:251 → 444
    TraB; TraB family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VG01 Q9VG01

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases