U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

solo sisters on the loose [ Drosophila melanogaster (fruit fly) ]

Gene ID: 26067079, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
soloprovided by FlyBase
Official Full Name
sisters on the looseprovided by FlyBase
Primary source
FLYBASE:FBgn0283440
Locus tag
Dmel_CG46282
See related
AllianceGenome:FB:FBgn0283440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS00929.15; CG33678; CG43081; CG46282; cgt; Dmel\CG46282; fs(2)ltoRJ36; pf7; Solo; SOLO
Summary
Enables SMC family protein binding activity. Involved in female meiotic nuclear division; meiotic sister chromatid cohesion, centromeric; and synaptonemal complex organization. Located in chromosome, centromeric region. Colocalizes with synaptonemal complex. Is expressed in germarium and germline cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See solo in Genome Data Viewer
Location:
35B10-35C1; 2-51 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15061656..15072133)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene crinkled Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II elongation factor Neighboring gene vasa Neighboring gene vasa intronic gene Neighboring gene white walker Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NT_033779.5 Chromosome 2L Reference Release 6 plus ISO1 MT Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Homolog pairing and sister chromatid cohesion in heterochromatin in Drosophila male meiosis I. Tsai JH, et al. Chromosoma, 2011 Aug. PMID 21384262
  2. The cohesion protein SOLO associates with SMC1 and is required for synapsis, recombination, homolog bias and cohesion and pairing of centromeres in Drosophila Meiosis. Yan R, et al. PLoS Genet, 2013. PMID 23874232, Free PMC Article
  3. piRNA silencing contributes to interspecies hybrid sterility and reproductive isolation in Drosophila melanogaster. Kotov AA, et al. Nucleic Acids Res, 2019 May 7. PMID 30788506, Free PMC Article
  4. SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster. Yan R, et al. J Cell Biol, 2010 Feb 8. PMID 20142422, Free PMC Article
  5. Centromere pairing--tethering partner chromosomes in meiosis I. Kurdzo EL, et al. FEBS J, 2015 Jul. PMID 25817724, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SMC family protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic sister chromatid cohesion, centromeric IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptonemal complex organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with synaptonemal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
sisters on the loose
Names
CG46282-PA
CG46282-PB
courgette
female sterile(2)ltoRJ36
no-relish
solo-PA
solo-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    15061656..15072133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032103.2 → NP_001027274.2  sisters on the loose, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027274.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B6JUP5, Q4ABF3
    UniProtKB/TrEMBL
    A0A0S0WFC5

  2. NM_001316394.1 → NP_001303323.1  sisters on the loose, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B6JUP5, Q4ABF3
    UniProtKB/TrEMBL
    A0A0S0WFC5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0WFC5 A0A0S0WFC5
B6JUP5.1 B6JUP5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases