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meep meep [ Drosophila melanogaster (fruit fly) ]

Gene ID: 261663, updated on 9-Dec-2024

Summary

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Official Symbol
meepprovided by FlyBase
Official Full Name
meepprovided by FlyBase
Primary source
FLYBASE:FBgn0063667
Locus tag
Dmel_CG32335
See related
AllianceGenome:FB:FBgn0063667
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE72485; CG32335; Dmel\CG32335
Summary
Enables hydrolase activity, acting on ester bonds. Involved in cellular response to glucose stimulus and positive regulation of insulin receptor signaling pathway. Predicted to be active in nucleus. Orthologous to human C11orf54 (chromosome 11 open reading frame 54). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See meep in Genome Data Viewer
Location:
61F3-61F3; 3-0 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1201871..1203036, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1201871..1203036, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Lysozyme X Neighboring gene APPL-interacting protein 1 Neighboring gene multiple wing hairs Neighboring gene uncharacterized protein Neighboring gene Lysozyme B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Meep, a Novel Regulator of Insulin Signaling, Supports Development and Insulin Sensitivity via Maintenance of Protein Homeostasis in Drosophila melanogaster. Pereira MT, et al. G3 (Bethesda), 2020 Dec 3. PMID 32998936, Free PMC Article
  2. Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold. Manjasetty BA, et al. Protein Sci, 2006 Apr. PMID 16522806, Free PMC Article
  3. The microbiome stabilizes circadian rhythms in the gut. Zhang Y, et al. Proc Natl Acad Sci U S A, 2023 Jan 31. PMID 36689661, Free PMC Article
  4. Hematopoietic plasticity mapped in Drosophila and other insects. Hultmark D, et al. Elife, 2022 Aug 3. PMID 35920811, Free PMC Article
  5. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, acting on ester bonds IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in triglyceride homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
meep
Names
CG32335-PB
meep-PB
NP_728575.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1201871..1203036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167858.4 → NP_728575.2  meep [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728575.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRI0, Q8SXQ8
    Conserved Domains (1) summary
    pfam08925
    Location:31 → 310
    DUF1907; Domain of Unknown Function (DUF1907)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SXQ8 Q8SXQ8

Gene LinkOut

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