mt-Nd6 NADH dehydrogenase 6, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: mt-Nd6provided by RGD
Official Full Name: NADH dehydrogenase 6, mitochondrialprovided by RGD
Primary source: RGD:620561
See related: AllianceGenome:RGD:620561
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus (strain: BN/SsNHsdMCW)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ND6
Summary: Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in response to cocaine; response to hydrogen peroxide; and response to nicotine. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Leigh disease; and spinal muscular atrophy with lower extremity predominant 2B. Orthologous to human MT-ND6 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
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Annotation release	Status	Assembly	Chr	Location
RS_2023_06	latest, but not current	mRatBN7.2 (GCF_015227675.2)	MT (non-nuclear)	NC_001665.2 (13543..14061, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	MT (non-nuclear)	NC_001665.2 (13543..14061, complement)

Chromosome MT - NC_001665.2 Genomic Context describing neighboring genes

Genomic Sequence:

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Function	Evidence Code	Pubs
enables NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
part_of respiratory chain complex I	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain