ARL5A ARF like GTPase 5A [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARL5Aprovided by HGNC
Official Full Name: ARF like GTPase 5Aprovided by HGNC
Primary source: HGNC:HGNC:696
See related: Ensembl:ENSG00000162980 MIM:608960; AllianceGenome:HGNC:696
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARL5; ARFLP5
Summary: The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thyroid (RPKM 27.2), heart (RPKM 19.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q23.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (151798797..151828421, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (152250228..152279855, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (152655311..152684935, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ARFRP1 functions upstream of two other ARL GTPases, ARL1 and ARL5, which in turn recruit golgins and GARP, respectively, to the trans-Golgi network (TGN).
Title: ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.
Arl5, an ARF-like family small GTPase, interacts with Ragulator in an amino acid-regulated manner and both Arl5 and its effector, the Golgi-associated retrograde protein complex (GARP), are required for the AA-stimulated trafficking.
Title: Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5.
microRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5A in human colorectal carcinoma.
Title: microRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5A in human colorectal carcinoma.
crystal structure
Title: 2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins.
developmentally regulated ARL5, with its distinctive nuclear/nucleolar localization and interaction with HP1alpha, may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development
Title: A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	Genome-wide shRNA screening identifies ARL5A, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to Golgi membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 5A

Names: ADP ribosylation factor like GTPase 5A; ADP-ribosylation factor-like 5; ADP-ribosylation factor-like 5A; ADP-ribosylation factor-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037174.2 → NP_001032251.1 ADP-ribosylation factor-like protein 5A isoform 2

See identical proteins and their annotated locations for NP_001032251.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks alternate segments in the 5' UTR and coding region compared to variant 1, resulting in a shorter isoform (2) compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AC097448

Consensus CDS

CCDS46425.1

UniProtKB/TrEMBL

B4DQS7

Conserved Domains (1) summary

cl38936
Location:1 → 138

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_012097.4 → NP_036229.1 ADP-ribosylation factor-like protein 5A isoform 1

See identical proteins and their annotated locations for NP_036229.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC097448

Consensus CDS

CCDS2195.1

UniProtKB/Swiss-Prot

Q580I5, Q9Y689

Related

ENSP00000295087.8, ENST00000295087.13

Conserved Domains (1) summary

cd04153
Location:3 → 175

Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases
NM_177985.3 → NP_817114.2 ADP-ribosylation factor-like protein 5A isoform 2

See identical proteins and their annotated locations for NP_817114.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR and coding region compared to variant 1, resulting in a shorter isoform (2) compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AC097448, BX461356, CX867116

Consensus CDS

CCDS46425.1

UniProtKB/TrEMBL

B4DQS7

Related

ENSP00000415950.1, ENST00000428992.2

Conserved Domains (1) summary

cl38936
Location:1 → 138

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases