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FBXO24 F-box protein 24 [ Homo sapiens (human) ]

Gene ID: 26261, updated on 27-Nov-2024

Summary

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Official Symbol
FBXO24provided by HGNC
Official Full Name
F-box protein 24provided by HGNC
Primary source
HGNC:HGNC:13595
See related
Ensembl:ENSG00000106336 MIM:609097; AllianceGenome:HGNC:13595
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX24
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Expression
Restricted expression toward testis (RPKM 14.9) See more
Orthologs
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Genomic context

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See FBXO24 in Genome Data Viewer
Location:
7q22.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100586328..100601117)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101826411..101841198)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100183951..100198740)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100172387-100172941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100172942-100173495 Neighboring gene Sin3A associated protein 25 Neighboring gene leucine rich repeats and calponin homology domain containing 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100181227-100181915 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100182061-100182574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100182575-100183088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18445 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100187581-100188381 Neighboring gene PCOLCE antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100201095-100201887 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26376 Neighboring gene procollagen C-endopeptidase enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18450 Neighboring gene motile sperm domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting LSD1 for Ubiquitination. Dong B, et al. Mol Cancer Res, 2023 Dec 1. PMID 37540490, Free PMC Article
  2. SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6. Chen W, et al. Biochem Biophys Res Commun, 2020 Sep 10. PMID 32828318
  3. FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration. El-Mergawy R, et al. J Biol Chem, 2024 Jun. PMID 38735474, Free PMC Article
  4. The ubiquitin E3 ligase SCF-FBXO24 recognizes deacetylated nucleoside diphosphate kinase A to enhance its degradation. Chen W, et al. Mol Cell Biol, 2015 Mar. PMID 25582197, Free PMC Article
  5. FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility. Li Z, et al. Elife, 2024 Mar 12. PMID 38470475, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration.
    Title: FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration.
  2. FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility.
    Title: FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility.
  3. FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting LSD1 for Ubiquitination.
    Title: FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting LSD1 for Ubiquitination.
  4. SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6.
    Title: SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434I1122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
F-box only protein 24
Names
F-box protein Fbx24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163499.2 → NP_001156971.1  F-box only protein 24 isoform 4

    See identical proteins and their annotated locations for NP_001156971.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter, 5' UTR, and 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK302252, BC067293
    Consensus CDS
    CCDS55138.1
    UniProtKB/Swiss-Prot
    O75426
    Related
    ENSP00000420239.1, ENST00000468962.5
    Conserved Domains (2) summary
    pfam00415
    Location:364 → 410
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam12937
    Location:31 → 73
    F-box-like; F-box-like

  2. NM_012172.5 → NP_036304.2  F-box only protein 24 isoform 3

    See identical proteins and their annotated locations for NP_036304.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter, 5' UTR, and 5' coding region, compared to variant 1. The resulting isoform (3) has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK301864, BC067293, DC397982
    Consensus CDS
    CCDS5699.2
    UniProtKB/Swiss-Prot
    O75426
    Related
    ENSP00000416558.2, ENST00000427939.2
    Conserved Domains (2) summary
    pfam00415
    Location:414 → 460
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam12937
    Location:81 → 123
    F-box-like; F-box-like

  3. NM_033506.3 → NP_277041.1  F-box only protein 24 isoform 1

    See identical proteins and their annotated locations for NP_277041.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC069281, BC067293, BU656991
    Consensus CDS
    CCDS5698.1
    UniProtKB/Swiss-Prot
    A4D2D4, B4DX91, B4DY42, O75426, Q9H0G1
    UniProtKB/TrEMBL
    A4D2D3
    Related
    ENSP00000241071.6, ENST00000241071.11
    Conserved Domains (2) summary
    pfam00415
    Location:376 → 422
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam12937
    Location:43 → 83
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    100586328..100601117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420182.1 → XP_047276138.1  F-box only protein 24 isoform X3

  2. XM_011516022.1 → XP_011514324.1  F-box only protein 24 isoform X1

    Conserved Domains (2) summary
    pfam00415
    Location:381 → 427
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam12937
    Location:48 → 90
    F-box-like; F-box-like

  3. XM_047420183.1 → XP_047276139.1  F-box only protein 24 isoform X4

  4. XM_005250259.5 → XP_005250316.1  F-box only protein 24 isoform X2

    Conserved Domains (2) summary
    pfam00415
    Location:414 → 442
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam12937
    Location:81 → 123
    F-box-like; F-box-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    101826411..101841198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357860.1 → XP_054213835.1  F-box only protein 24 isoform X3

  2. XM_054357858.1 → XP_054213833.1  F-box only protein 24 isoform X1

  3. XM_054357861.1 → XP_054213836.1  F-box only protein 24 isoform X4

  4. XM_054357859.1 → XP_054213834.1  F-box only protein 24 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75426.2 GenPept UniProtKB/Swiss-Prot:O75426

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