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Map2k7 mitogen-activated protein kinase kinase 7 [ Mus musculus (house mouse) ]

Gene ID: 26400, updated on 27-Nov-2024

Summary

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Official Symbol
Map2k7provided by MGI
Official Full Name
mitogen-activated protein kinase kinase 7provided by MGI
Primary source
MGI:MGI:1346871
See related
Ensembl:ENSMUSG00000002948 AllianceGenome:MGI:1346871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mek7; Mkk7; sek2; Jnkk2; MEK 7; JNKK 2; Mapkk7; Prkmk7; MAPKK 7; 5930412N11Rik
Summary
Enables magnesium ion binding activity; protein kinase activity; and protein phosphatase binding activity. Involved in several processes, including JNK cascade; cellular response to lipopolysaccharide; and positive regulation of MAPK cascade. Acts upstream of or within regulation of motor neuron apoptotic process and response to wounding. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; lung; musculoskeletal system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; lung carcinoma; and lung non-small cell carcinoma. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 34.8), adrenal adult (RPKM 26.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Map2k7 in Genome Data Viewer
Location:
8 A1.1; 8 1.99 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4288740..4297897)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4238740..4247897)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20610 Neighboring gene proline rich 36 Neighboring gene leucine rich repeat containing 8 family, member E Neighboring gene transforming growth factor, beta receptor III-like Neighboring gene small nuclear RNA activating complex, polypeptide 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A change of expression in the conserved signaling gene MKK7 is associated with a selective sweep in the western house mouse Mus musculus domesticus. Harr B, et al. J Evol Biol, 2006 Sep. PMID 16910979
  2. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Wada T, et al. Nat Cell Biol, 2004 Mar. PMID 15039780
  3. The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task. Openshaw RL, et al. Dis Model Mech, 2022 Mar 1. PMID 35275161, Free PMC Article
  4. Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects. Petrich BG, et al. J Biol Chem, 2004 Apr 9. PMID 14742426
  5. Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload. Liu W, et al. J Mol Cell Cardiol, 2011 Apr. PMID 21284947

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer.
    Title: Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer.
  2. The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task.
    Title: The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task.
  3. Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells.
    Title: Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells.
  4. Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice.
    Title: Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice.
  5. MKK7 deficiency in mature neurons impairs parental behavior in mice.
    Title: MKK7 deficiency in mature neurons impairs parental behavior in mice.
  6. Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia.
    Title: Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia.
  7. These results suggest that MKK4 and MKK7 may serve redundant and unique roles in molecular signaling important for retinal development and injury response following axonal insult.
    Title: Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death.
  8. we generated neuron-specific Mkk7 knockout mice (MKK7 cKO), which impaired constitutive activation of JNK in the nervous system. MKK7 cKO mice displayed impaired circadian behavioral rhythms and decreased locomotor activity. MKK7 cKO mice at 8 months showed motor dysfunctions such as weakness of hind-limb and gait abnormality in an age-dependent manner.
    Title: Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7.
  9. SENP3 potentiates lipopolysaccharide-induced TLR4 signaling via deSUMOylation of MKK7 leading to enhancement in JNK phosphorylation and the downstream events
    Title: DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages.
  10. High Map2k7 expression is associated with T-cell acute lymphoblastic leukemia.
    Title: Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (7)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables JUN kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables JUN kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables JUN kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AXY142 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3Y41 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to osmotic stress ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to UV IEA
Inferred from Electronic Annotation
more info
  
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
  
involved_in response to heat ISO
Inferred from Sequence Orthology
more info
  
involved_in response to osmotic stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to osmotic stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
  
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dual specificity mitogen-activated protein kinase kinase 7
Names
JNK kinase 2
JNK-activating kinase 2
MAP kinase kinase 7
MAPK/ERK kinase 7
c-Jun N-terminal kinase kinase 2
protein kinase, mitogen activated, kinase 7
NP_001036022.1
NP_001157644.1
NP_001278706.1
NP_001278707.1
NP_001278712.1
NP_036074.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042557.2 → NP_001036022.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 1

    See identical proteins and their annotated locations for NP_001036022.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB005654, BB842920
    Consensus CDS
    CCDS40208.1
    UniProtKB/Swiss-Prot
    O35406, O35720, O35871, O35872, O54780, O70242, O70243, Q8BSP1, Q8CE90, Q9QWG6, Q9R1Z3, Q9R1Z4, Q9R1Z5, Q9R1Z6
    Related
    ENSMUSP00000003027.8, ENSMUST00000003027.14
    Conserved Domains (2) summary
    smart00220
    Location:137 → 396
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06618
    Location:120 → 416
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

  2. NM_001164172.1 → NP_001157644.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 3

    See identical proteins and their annotated locations for NP_001157644.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) retains the last intron compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC123029, BB842920, BC070467
    Consensus CDS
    CCDS52474.1
    UniProtKB/Swiss-Prot
    O35406, O35720, O35871, O35872, O54780, O70242, O70243, Q8BSP1, Q8CE90, Q9QWG6, Q9R1Z3, Q9R1Z4, Q9R1Z5, Q9R1Z6
    Related
    ENSMUSP00000054512.5, ENSMUST00000062686.11
    Conserved Domains (1) summary
    cd06618
    Location:120 → 416
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

  3. NM_001291777.1 → NP_001278706.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 4

    See identical proteins and their annotated locations for NP_001278706.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB005654, AK165184, BB842920
    Consensus CDS
    CCDS80852.1
    UniProtKB/Swiss-Prot
    Q8CE90
    Related
    ENSMUSP00000106627.2, ENSMUST00000110999.8
    Conserved Domains (2) summary
    smart00220
    Location:121 → 380
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06618
    Location:104 → 400
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

  4. NM_001291778.1 → NP_001278707.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 5

    See identical proteins and their annotated locations for NP_001278707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AB005654, AC123029
    Consensus CDS
    CCDS80853.1
    UniProtKB/Swiss-Prot
    Q8CE90
    Related
    ENSMUSP00000106623.2, ENSMUST00000110995.8
    Conserved Domains (1) summary
    cd06618
    Location:31 → 327
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

  5. NM_001291783.1 → NP_001278712.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 6

    See identical proteins and their annotated locations for NP_001278712.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and retains the last intron compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC123029, AF060944, AK049267, BC070467
    Consensus CDS
    CCDS80854.1
    UniProtKB/Swiss-Prot
    Q8CE90
    Related
    ENSMUSP00000106622.2, ENSMUST00000110994.9
    Conserved Domains (1) summary
    cd06618
    Location:31 → 327
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

  6. NM_011944.3 → NP_036074.2  dual specificity mitogen-activated protein kinase kinase 7 isoform 2

    See identical proteins and their annotated locations for NP_036074.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and retains the last intron compared to variant 1. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC123029, AK165184, BB842920, CO044477
    Consensus CDS
    CCDS40209.1
    UniProtKB/Swiss-Prot
    Q8CE90
    Related
    ENSMUSP00000106626.3, ENSMUST00000110998.9
    Conserved Domains (1) summary
    cd06618
    Location:104 → 400
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    4288740..4297897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CE90.1 GenPept UniProtKB/Swiss-Prot:Q8CE90

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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