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Mapk10 mitogen-activated protein kinase 10 [ Mus musculus (house mouse) ]

Gene ID: 26414, updated on 27-Nov-2024

Summary

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Official Symbol
Mapk10provided by MGI
Official Full Name
mitogen-activated protein kinase 10provided by MGI
Primary source
MGI:MGI:1346863
See related
Ensembl:ENSMUSG00000046709 AllianceGenome:MGI:1346863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JNK3; Serk2; JNK3B1; JNK3B2; p493F12; p54bSAPK; SAPK(beta); C230008H04Rik
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression
Biased expression in cortex adult (RPKM 28.0), frontal lobe adult (RPKM 20.7) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Mapk10 in Genome Data Viewer
Location:
5 E5; 5 49.61 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (103056413..103359200, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (102908547..103212604, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 24 Neighboring gene STARR-positive B cell enhancer ABC_E2753 Neighboring gene STARR-positive B cell enhancer ABC_E2754 Neighboring gene STARR-positive B cell enhancer ABC_E8065 Neighboring gene ferredoxin 1-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_13764 Neighboring gene predicted gene, 30396 Neighboring gene STARR-seq mESC enhancer starr_13765 Neighboring gene STARR-seq mESC enhancer starr_13766 Neighboring gene STARR-seq mESC enhancer starr_13767 Neighboring gene STARR-seq mESC enhancer starr_13768 Neighboring gene STARR-seq mESC enhancer starr_13769 Neighboring gene STARR-seq mESC enhancer starr_13770 Neighboring gene STARR-seq mESC enhancer starr_13772 Neighboring gene RIKEN cDNA 4930429D17 gene Neighboring gene STARR-seq mESC enhancer starr_13773 Neighboring gene STARR-seq mESC enhancer starr_13774 Neighboring gene RIKEN cDNA 1700021F02 gene Neighboring gene STARR-seq mESC enhancer starr_13775 Neighboring gene discs, large homolog 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction. Yu J, et al. J Biol Chem, 2007 Aug 31. PMID 17609208
  2. Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly increases disease severity in a mouse model of multiple sclerosis. Priego M, et al. J Neuroimmunol, 2023 Sep 15. PMID 37454525, Free PMC Article
  3. Time series RNA-seq analysis identifies MAPK10 as a critical gene in diabetes mellitus-induced atrial fibrillation in mice. Liu F, et al. J Mol Cell Cardiol, 2022 Jul. PMID 35489387
  4. Neuroprotective role of PrPC against kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6/7-PSD-95 binding. Carulla P, et al. Mol Biol Cell, 2011 Sep. PMID 21757544, Free PMC Article
  5. Lack of neuroprotection against experimental glaucoma in c-Jun N-terminal kinase 3 knockout mice. Quigley HA, et al. Exp Eye Res, 2011 Apr. PMID 21272576, Free PMC Article

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral sensitization.
    Title: Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral sensitization.
  2. Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly increases disease severity in a mouse model of multiple sclerosis.
    Title: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly increases disease severity in a mouse model of multiple sclerosis.
  3. Time series RNA-seq analysis identifies MAPK10 as a critical gene in diabetes mellitus-induced atrial fibrillation in mice.
    Title: Time series RNA-seq analysis identifies MAPK10 as a critical gene in diabetes mellitus-induced atrial fibrillation in mice.
  4. JNK3 deficiency leads to upregulation of growth factors such as Vegfa, Pdgfb, Pgf, Hbegf and Tgfb3 in ischemic muscle by activation of the transcription factors Egr1/Creb1.
    Title: Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis.
  5. JNK isoforms are involved in the adult neurogenesis control.
    Title: JNK Isoforms Are Involved in the Control of Adult Hippocampal Neurogenesis in Mice, Both in Physiological Conditions and in an Experimental Model of Temporal Lobe Epilepsy.
  6. Together these data indicate that ONA induces APP expression and that gamma-secretase cleavage of APP releases AICD, which upregulates JNK3 leading to RGC death. This pathway may be a novel target for neuronal protection in optic neuropathies and other forms of neurotrauma.
    Title: APP upregulation contributes to retinal ganglion cell degeneration via JNK3.
  7. JNK1 and/or JNK3 are promising targets for the prevention of cell death and inflammation during epileptogenesis.
    Title: Neuroprotective Effects of the Absence of JNK1 or JNK3 Isoforms on Kainic Acid-Induced Temporal Lobe Epilepsy-Like Symptoms.
  8. Conversely, treatment with LY294002 (a selective inhibitor of Akt1) reversed the effects of quercetin. In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt signaling pathway. We believe that quercetin might prove to be a useful therapeutic component in treating cerebral I/R diseases in the near future.
    Title: Quercetin ameliorates ischemia/reperfusion-induced cognitive deficits by inhibiting ASK1/JNK3/caspase-3 by enhancing the Akt signaling pathway.
  9. JNK3 therefore provides a mechanism that contributes to homeostatic regulation of energy balance in response to metabolic stress.
    Title: Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress.
  10. Genetic inhibition of JNK pathway in vivo by Jnk3 knockout results in amelioration of spinal muscular atrophy phenotype
    Title: Genetic inhibition of JNK3 ameliorates spinal muscular atrophy.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables JUN kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables JUN kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter receptor transport to postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport in synapse ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase 10
Names
JNK3 beta1 protein kinase
JNK3 beta2 protein kinase
MAP kinase 10
MAP kinase p49 3F12
SAPK/Erk/kinase 2
c-Jun N-terminal kinase 3
stress-activated protein kinase JNK3
NP_001075036.1
NP_001297612.1
NP_001297614.1
NP_001297615.1
NP_001305031.1
NP_001305060.1
NP_001394501.1
NP_001394502.1
NP_001394503.1
NP_001394504.1
NP_001394505.1
NP_001394506.1
NP_001394507.1
NP_001394508.1
NP_001394509.1
NP_001394513.1
NP_001394515.1
NP_001394517.1
NP_001394518.1
NP_001394521.1
NP_001394524.1
NP_001394528.1
NP_001394529.1
NP_001394530.1
NP_033184.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081567.3 → NP_001075036.1  mitogen-activated protein kinase 10 isoform 1

    See identical proteins and their annotated locations for NP_001075036.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also know as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    Consensus CDS
    CCDS39185.1
    UniProtKB/Swiss-Prot
    Q61831, Q9R0U6
    UniProtKB/TrEMBL
    Q8C9D4
    Related
    ENSMUSP00000108468.3, ENSMUST00000112847.9
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. NM_001310683.2 → NP_001297612.1  mitogen-activated protein kinase 10 isoform 3

    See identical proteins and their annotated locations for NP_001297612.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site in the 5' region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/Swiss-Prot
    Q61831, Q9R0U6
    UniProtKB/TrEMBL
    Q78GB8
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  3. NM_001310685.2 → NP_001297614.1  mitogen-activated protein kinase 10 isoform 4

    See identical proteins and their annotated locations for NP_001297614.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame coding exon compared to variant 1. The resulting isoform (4, also known as JNK3 beta2) is the same length; however, contains a different 24 aa protein segment compared to isoform 1.
    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    Consensus CDS
    CCDS80350.1
    UniProtKB/Swiss-Prot
    Q61831, Q9R0U6
    UniProtKB/TrEMBL
    Q80W80
    Related
    ENSMUSP00000084065.4, ENSMUST00000086854.10
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  4. NM_001310686.3 → NP_001297615.1  mitogen-activated protein kinase 10 isoform 5

    See identical proteins and their annotated locations for NP_001297615.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate acceptor splice site in the 5' region and at the 3' terminal exon compared to variant 1. These differences result in translation initiation from an in-frame, downstream start codon, and an isoform (5) with a shorter N-terminus and a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/Swiss-Prot
    Q61831, Q9R0U6
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  5. NM_001318102.1 → NP_001305031.1  mitogen-activated protein kinase 10 isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also know as JNK3 alpha1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AC125252, AC137121, AK082242, BC046625
    Consensus CDS
    CCDS89959.1
    UniProtKB/Swiss-Prot
    Q61831, Q9R0U6
    UniProtKB/TrEMBL
    A0A5F8MP75
    Related
    ENSMUSP00000158744.3, ENSMUST00000238446.3
    Conserved Domains (2) summary
    smart00220
    Location:64 → 359
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  6. NM_001318131.2 → NP_001305060.1  mitogen-activated protein kinase 10 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate in-frame coding exon and uses an alternate acceptor splice site at the 3' terminal exon (which causes a frameshift) compared to variant 1. The resulting isoform (6, also known as JNK3 beta1) has a different, internal 24 aa protein segment and a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/Swiss-Prot
    Q61831, Q9R0U6
    UniProtKB/TrEMBL
    Q80W81
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  7. NM_001407572.1 → NP_001394501.1  mitogen-activated protein kinase 10 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121
    UniProtKB/TrEMBL
    E9QN59
    Related
    ENSMUSP00000108469.2, ENSMUST00000112848.8

  8. NM_001407573.1 → NP_001394502.1  mitogen-activated protein kinase 10 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    Q8C9D4

  9. NM_001407574.1 → NP_001394503.1  mitogen-activated protein kinase 10 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    Q8C9D4

  10. NM_001407575.1 → NP_001394504.1  mitogen-activated protein kinase 10 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    Q8C9D4

  11. NM_001407576.1 → NP_001394505.1  mitogen-activated protein kinase 10 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244

  12. NM_001407577.1 → NP_001394506.1  mitogen-activated protein kinase 10 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    Q78GB8

  13. NM_001407578.1 → NP_001394507.1  mitogen-activated protein kinase 10 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    Q78GB8

  14. NM_001407579.1 → NP_001394508.1  mitogen-activated protein kinase 10 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    Q78GB8

  15. NM_001407580.1 → NP_001394509.1  mitogen-activated protein kinase 10 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244

  16. NM_001407584.1 → NP_001394513.1  mitogen-activated protein kinase 10 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    Q80W82

  17. NM_001407586.1 → NP_001394515.1  mitogen-activated protein kinase 10 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244

  18. NM_001407588.1 → NP_001394517.1  mitogen-activated protein kinase 10 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121

  19. NM_001407589.1 → NP_001394518.1  mitogen-activated protein kinase 10 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121

  20. NM_001407592.1 → NP_001394521.1  mitogen-activated protein kinase 10 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244

  21. NM_001407595.1 → NP_001394524.1  mitogen-activated protein kinase 10 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244

  22. NM_001407599.1 → NP_001394528.1  mitogen-activated protein kinase 10 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244

  23. NM_001407600.1 → NP_001394529.1  mitogen-activated protein kinase 10 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC137121
    UniProtKB/TrEMBL
    A0A0G2JG69
    Related
    ENSMUSP00000143448.2, ENSMUST00000128869.8

  24. NM_001407601.1 → NP_001394530.1  mitogen-activated protein kinase 10 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244

  25. NM_009158.4 → NP_033184.2  mitogen-activated protein kinase 10 isoform 2

    See identical proteins and their annotated locations for NP_033184.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting isoform (2, also know as JNK3 alpha1) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/Swiss-Prot
    Q61831, Q9R0U6
    UniProtKB/TrEMBL
    Q80W82
    Related
    ENSMUSP00000159947.1, ENSMUST00000249849.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RNA

  1. NR_176398.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC160244
    Related
    ENSMUST00000152609.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    103056413..103359200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61831.2 GenPept UniProtKB/Swiss-Prot:Q61831

Gene LinkOut

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