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LATS2 large tumor suppressor kinase 2 [ Homo sapiens (human) ]

Gene ID: 26524, updated on 27-Nov-2024

Summary

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Official Symbol
LATS2provided by HGNC
Official Full Name
large tumor suppressor kinase 2provided by HGNC
Primary source
HGNC:HGNC:6515
See related
Ensembl:ENSG00000150457 MIM:604861; AllianceGenome:HGNC:6515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KPM
Summary
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 10.9), gall bladder (RPKM 10.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See LATS2 in Genome Data Viewer
Location:
13q12.11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (20973036..21061586, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (20166164..20254674, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21547175..21635725, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein SA pseudogene 54 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:21549761-21550262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21571219-21571758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21572540-21573076 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21608126-21608626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21609627-21610451 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21611543-21612531 Neighboring gene RNA, U4 small nuclear 9, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21624857-21625356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21626645-21627146 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21634192-21635084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5160 Neighboring gene uncharacterized LOC105370104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:21649238-21649738 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:21649739-21650239 Neighboring gene ribosomal protein S12 pseudogene 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LATS2 is de-methylated and overexpressed in nasopharyngeal carcinoma and predicts poor prognosis. Zhang Y, et al. BMC Cancer, 2010 Oct 8. PMID 20932276, Free PMC Article
  2. Down-regulation of LATS2 in non-small cell lung cancer promoted the growth and motility of cancer cells. Yao F, et al. Tumour Biol, 2015 Mar. PMID 25391426
  3. Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas. Luo SY, et al. Lung Cancer, 2014 Aug. PMID 24976335, Free PMC Article
  4. Promoter Hypermethylation of LATS2 Gene in Oral Squamous Cell Carcinoma (OSCC) Among North Indian Population. Goel H, et al. Asian Pac J Cancer Prev, 2020 May 1. PMID 32458634, Free PMC Article
  5. HTS-Compatible CometChip Enables Genetic Screening for Modulators of Apoptosis and DNA Double-Strand Break Repair. Tay IJ, et al. SLAS Discov, 2020 Sep. PMID 32452708

See all (206) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
    Title: A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
  2. MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2.
    Title: MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2.
  3. RNF106 aggravates esophageal squamous cell carcinoma progression through LATS2/YAP axis.
    Title: RNF106 aggravates esophageal squamous cell carcinoma progression through LATS2/YAP axis.
  4. Mir-629 Repressed LATS2 Expression and Promoted the Proliferation of Prostate Cancer Cells.
    Title: Mir-629 Repressed LATS2 Expression and Promoted the Proliferation of Prostate Cancer Cells.
  5. FBXO22 Accelerates Pancreatic Cancer Growth by Deactivation of the Hippo Pathway via Destabilizing LATS2.
    Title: FBXO22 Accelerates Pancreatic Cancer Growth by Deactivation of the Hippo Pathway via Destabilizing LATS2.
  6. The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation regulates angiogenesis and liver metastasis in colorectal cancer.
    Title: The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation regulates angiogenesis and liver metastasis in colorectal cancer.
  7. circPKD2 inhibits the glioma cell proliferation, invasion and glycolytic metabolism through regulating the miR-1278/LATS2 axis.
    Title: circPKD2 inhibits the glioma cell proliferation, invasion and glycolytic metabolism through regulating the miR-1278/LATS2 axis.
  8. Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.
    Title: Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.
  9. LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells.
    Title: LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells.
  10. Deathly triangle for pancreatic beta-cells: Hippo pathway-MTORC1-autophagy.
    Title: Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy.
Submit: New GeneRIF Correction See all GeneRIFs (138)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hippo signaling TAS
Traceable Author Statement
more info
  
involved_in hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inner cell mass cell fate commitment IEA
Inferred from Electronic Annotation
more info
  
involved_in inner cell mass cellular morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of organ growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase LATS2
Names
LATS (large tumor suppressor, Drosophila) homolog 2
LATS, large tumor suppressor, homolog 2
kinase phosphorylated during mitosis protein
large tumor suppressor homolog 2
serine/threonine kinase KPM
serine/threonine-protein kinase kpm
warts-like kinase
NP_055387.2
XP_005266399.1
XP_011533344.1
XP_016876030.1
XP_016876031.1
XP_047286222.1
XP_047286223.1
XP_054230417.1
XP_054230418.1
XP_054230419.1
XP_054230420.1
XP_054230421.1
XP_054230422.1
XP_054230423.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014572.3 → NP_055387.2  serine/threonine-protein kinase LATS2

    See identical proteins and their annotated locations for NP_055387.2

    Status: REVIEWED

    Source sequence(s)
    AF207547, AL161613, AL356285, BQ774580, DB452765
    Consensus CDS
    CCDS9294.1
    UniProtKB/Swiss-Prot
    B1AM47, Q9NRM7, Q9P2X1
    UniProtKB/TrEMBL
    Q59EB4
    Related
    ENSP00000372035.4, ENST00000382592.5
    Conserved Domains (3) summary
    cd05626
    Location:666 → 1046
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    smart00220
    Location:668 → 973
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14398
    Location:101 → 141
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    20973036..21061586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020542.2 → XP_016876031.1  serine/threonine-protein kinase LATS2 isoform X4

    UniProtKB/TrEMBL
    Q59EB4

  2. XM_005266342.1 → XP_005266399.1  serine/threonine-protein kinase LATS2 isoform X1

    See identical proteins and their annotated locations for XP_005266399.1

    UniProtKB/Swiss-Prot
    B1AM47, Q9NRM7, Q9P2X1
    UniProtKB/TrEMBL
    Q59EB4
    Conserved Domains (3) summary
    cd05626
    Location:666 → 1046
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    smart00220
    Location:668 → 973
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14398
    Location:101 → 141
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2

  3. XM_047430266.1 → XP_047286222.1  serine/threonine-protein kinase LATS2 isoform X1

    UniProtKB/Swiss-Prot
    B1AM47, Q9NRM7, Q9P2X1

  4. XM_047430267.1 → XP_047286223.1  serine/threonine-protein kinase LATS2 isoform X4

  5. XM_017020541.2 → XP_016876030.1  serine/threonine-protein kinase LATS2 isoform X3

    UniProtKB/TrEMBL
    Q59EB4

  6. XM_011535042.3 → XP_011533344.1  serine/threonine-protein kinase LATS2 isoform X2

    Conserved Domains (3) summary
    cd05626
    Location:579 → 959
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    smart00220
    Location:581 → 886
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21463
    Location:24 → 54
    UBA_like_SF; UBA domain-like superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    20166164..20254674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374447.1 → XP_054230422.1  serine/threonine-protein kinase LATS2 isoform X4

  2. XM_054374443.1 → XP_054230418.1  serine/threonine-protein kinase LATS2 isoform X1

  3. XM_054374444.1 → XP_054230419.1  serine/threonine-protein kinase LATS2 isoform X1

  4. XM_054374448.1 → XP_054230423.1  serine/threonine-protein kinase LATS2 isoform X4

  5. XM_054374442.1 → XP_054230417.1  serine/threonine-protein kinase LATS2 isoform X1

  6. XM_054374446.1 → XP_054230421.1  serine/threonine-protein kinase LATS2 isoform X3

  7. XM_054374445.1 → XP_054230420.1  serine/threonine-protein kinase LATS2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRM7.2 GenPept UniProtKB/Swiss-Prot:Q9NRM7

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