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sptl-2 Serine palmitoyltransferase 2 [ Caenorhabditis elegans ]

Gene ID: 266646, updated on 2-Nov-2024

Summary

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Official Symbol
sptl-2
Official Full Name
Serine palmitoyltransferase 2
Primary source
WormBase:WBGene00018398
Locus tag
CELE_F43H9.2
See related
AllianceGenome:WB:WBGene00018398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine C-palmitoyltransferase activity. Predicted to be involved in ceramide biosynthetic process and sphingosine biosynthetic process. Predicted to be part of serine palmitoyltransferase complex. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1C. Orthologous to human SPTLC2 (serine palmitoyltransferase long chain base subunit 2) and SPTLC3 (serine palmitoyltransferase long chain base subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sptl-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (8017947..8021715)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II subunit rpb-9 Neighboring gene BSD domain-containing protein Neighboring gene Enoyl-CoA hydratase Neighboring gene Polymerase nucleotidyl transferase domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of Caenorhabditis elegans phosphoproteome reveals the involvement of a molecular chaperone, HSP-90 protein during Salmonella enterica Serovar Typhi infection. Balasubramaniam B, et al. Int J Biol Macromol, 2019 Sep 15. PMID 31252012
  2. Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. Zhang H, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926990, Free PMC Article
  3. The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress. Li TY, et al. Nat Aging, 2021 Feb. PMID 33718883, Free PMC Article
  4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables serine C-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine C-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of serine palmitoyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Serine palmitoyltransferase 2
NP_505064.1
  • Confirmed by transcript evidence
NP_505065.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8017947..8021715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072663.7 → NP_505064.1  Serine palmitoyltransferase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505064.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20375
    Conserved Domains (2) summary
    PLN02483
    Location:103 → 585
    PLN02483; serine palmitoyltransferase
    COG0156
    Location:184 → 562
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]

  2. NM_072664.6 → NP_505065.1  Serine palmitoyltransferase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505065.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20375, Q95ZT7
    Conserved Domains (2) summary
    PLN02483
    Location:75 → 557
    PLN02483; serine palmitoyltransferase
    COG0156
    Location:156 → 534
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20375.1

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