cas-2 C-CAP/cofactor C-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cas-2
Official Full Name: C-CAP/cofactor C-like domain-containing protein
Primary source: WormBase:WBGene00015975
Locus tag: CELE_C18E3.6
See related: AllianceGenome:WB:WBGene00015975
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables actin monomer binding activity and adenyl-nucleotide exchange factor activity. Involved in positive regulation of actin filament polymerization. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1) and CAP2 (cyclase associated actin cytoskeleton regulatory protein 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cas-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (4190158..4193129)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

double mutation (V367A/I373A) eliminates these actin-regulatory functions of CAS-2. These hydrophobic residues and previously identified functional residues are scattered on a concave beta-sheet of the CARP domain, suggesting that a wide area of the beta-sheet is involved in binding to actin.
Title: Conserved hydrophobic residues in the CARP/β-sheet domain of cyclase-associated protein are involved in actin monomer regulation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C18E3.6 (e-PCR)
- UniSTS:305801

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	IDA Inferred from Direct Assay more info	PubMed
enables adenyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-CAP/cofactor C-like domain-containing protein

NP_001293294.1

Confirmed by transcript evidence

NP_491324.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4190158..4193129

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058923.8 → NP_491324.1 C-CAP/cofactor C-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491324.1

Status: REVIEWED

UniProtKB/TrEMBL

O02096

Conserved Domains (3) summary

smart00673
Location:375 → 411

CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product

pfam01213
Location:4 → 274

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:305 → 456

CAP_C; Adenylate cyclase associated (CAP) C terminal
NM_001306365.3 → NP_001293294.1 C-CAP/cofactor C-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293294.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ACX4

Conserved Domains (3) summary

smart00673
Location:211 → 247

CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product

pfam01213
Location:1 → 110

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:141 → 292

CAP_C; Adenylate cyclase associated (CAP) C terminal