let-607 CREB-H transcription factor homolog let-607 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: let-607
Official Full Name: CREB-H transcription factor homolog let-607
Primary source: WormBase:WBGene00002783
Locus tag: CELE_F57B10.1
See related: AllianceGenome:WB:WBGene00002783
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including protein folding; regulation of distal tip cell migration; and regulation of intracellular signal transduction. Located in chromatin. Is expressed in several structures, including coelomocyte; excretory cell; gonad; pseudocoelom; and somatic cell. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See let-607 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (6574004..6585173)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways.
Title: Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F57B10.1 (e-PCR)
- UniSTS:311894

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in negative regulation of protein kinase C signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein folding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of IRE1-mediated unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CREB-H transcription factor homolog let-607

NP_491897.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6574004..6585173

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059496.9 → NP_491897.2 CREB-H transcription factor homolog let-607 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491897.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O44743

Conserved Domains (2) summary

cd14689
Location:295 → 345

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

TIGR02168
Location:254 → 364

SMC_prok_B; chromosome segregation protein SMC, common bacterial type