stn-1 Syntrophin-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: stn-1
Official Full Name: Syntrophin-1
Primary source: WormBase:WBGene00006062
Locus tag: CELE_F30A10.8
See related: AllianceGenome:WB:WBGene00006062
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables acetylcholine transmembrane transporter activity and calcium channel regulator activity. Involved in several processes, including acetylcholine transport; muscle cell cellular homeostasis; and sarcomere organization. Part of dystrophin-associated glycoprotein complex. Is expressed in body wall musculature; enteric muscle; nervous system; and reproductive system. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 12; and sudden infant death syndrome. Orthologous to several human genes including SNTB2 (syntrophin beta 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See stn-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (9501268..9505173)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the role of syntrophin is linked to dystrophin function in C.elegans
Title: The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F30A10.8 (e-PCR)
- UniSTS:307573

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetylcholine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetylcholine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	TAS Traceable Author Statement more info	PubMed
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of backward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of egg-laying behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of forward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dystrophin-associated glycoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dystrophin-associated glycoprotein complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of dystrophin-associated glycoprotein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Syntrophin-1

NP_492521.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9501268..9505173

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060120.7 → NP_492521.1 Syntrophin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492521.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93646, Q9XVP8

Conserved Domains (4) summary

smart00233
Location:228 → 334

PH; Pleckstrin homology domain

cd00992
Location:44 → 125

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00169
Location:228 → 334

PH; PH domain

cl17171
Location:152 → 208

PH-like; Pleckstrin homology-like domain