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prdx-2 Peroxiredoxin prdx-2 [ Caenorhabditis elegans ]

Gene ID: 266858, updated on 9-Dec-2024

Summary

Official Symbol
prdx-2
Official Full Name
Peroxiredoxin prdx-2
Primary source
WormBase:WBGene00006434
Locus tag
CELE_F09E5.15
See related
AllianceGenome:WB:WBGene00006434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables thioredoxin peroxidase activity. Involved in several processes, including cellular response to hydrogen peroxide; determination of adult lifespan; and positive regulation of brood size. Located in cytoplasm. Is expressed in several structures, including intestine; nervous system; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See prdx-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (5378195..5379631)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Putative deoxyribose-phosphate aldolase Neighboring gene Alpha-1,3/1,6-mannosyltransferase ALG2 Neighboring gene ncRNA Neighboring gene Protein kinase C-like 3 Neighboring gene Cytosolic carboxypeptidase 6

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thioredoxin-dependent peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heat acclimation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of brood size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to chemical IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to metal ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Peroxiredoxin prdx-2
NP_001300536.1
  • Partially confirmed by transcript evidence
NP_001367731.1
  • Confirmed by transcript evidence
NP_001370635.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5378195..5379631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381416.1NP_001367731.1  Peroxiredoxin prdx-2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd03015
    Location:10181
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  2. NM_001313607.3NP_001300536.1  Peroxiredoxin prdx-2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3AUJ9, H2KZL7, Q8IG31
    Conserved Domains (1) summary
    cd03015
    Location:12183
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  3. NM_001383831.2NP_001370635.1  Peroxiredoxin prdx-2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd03015
    Location:6177
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...