Sars1 seryl-tRNA synthetase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sars1provided by RGD
Official Full Name: seryl-tRNA synthetase 1provided by RGD
Primary source: RGD:628813
See related: EnsemblRapid:ENSRNOG00000020255 AllianceGenome:RGD:628813
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sars
Summary: Predicted to enable several functions, including aminoacyl-tRNA ligase activity; nucleic acid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including negative regulation of angiogenesis; negative regulation of macromolecule biosynthetic process; and translation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 372.9), Muscle (RPKM 364.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (198753673..198769411, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (196065543..196081240, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (211219743..211235475, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF393290 (e-PCR)
- UniSTS:244054

MDB0358 (e-PCR)
- UniSTS:125017

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables selenocysteine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables selenocysteine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables selenocysteine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables serine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables serine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables serine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in selenocysteine incorporation	IEA Inferred from Electronic Annotation more info
involved_in selenocysteine incorporation	ISO Inferred from Sequence Orthology more info
involved_in selenocysteine incorporation	ISS Inferred from Sequence or Structural Similarity more info
involved_in seryl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in seryl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in seryl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in seryl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA modification	IEA Inferred from Electronic Annotation more info
involved_in tRNA modification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine--tRNA ligase, cytoplasmic

Names: serRS; seryl-aminoacyl-tRNA synthetase 1; seryl-tRNA synthetase, cytoplasmic; seryl-tRNA(Ser/Sec) synthetase

NP_001007607.1

EC 6.1.1.11

XP_006233198.1

EC 6.1.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007606.1 → NP_001007607.1 serine--tRNA ligase, cytoplasmic

See identical proteins and their annotated locations for NP_001007607.1

Status: PROVISIONAL

Source sequence(s)

BC061765

UniProtKB/Swiss-Prot

Q6P799, Q8CIQ8

UniProtKB/TrEMBL

A6HV02

Related

ENSRNOP00000038448.3, ENSRNOT00000033015.6

Conserved Domains (1) summary

PLN02678
Location:3 → 486

PLN02678; seryl-tRNA synthetase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

198753673..198769411 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233136.4 → XP_006233198.1 serine--tRNA ligase, cytoplasmic isoform X1

See identical proteins and their annotated locations for XP_006233198.1

UniProtKB/TrEMBL

A0A0G2JZG7, A6HV03

Related

ENSRNOP00000071040.1, ENSRNOT00000091896.3

Conserved Domains (3) summary

PLN02678
Location:3 → 510

PLN02678; seryl-tRNA synthetase

cd00770
Location:152 → 484

SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...

pfam02403
Location:3 → 72

Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain