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Ahsa2 AHA1, activator of heat shock protein ATPase 2 [ Mus musculus (house mouse) ]

Gene ID: 268390, updated on 27-Nov-2024

Summary

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Official Symbol
Ahsa2provided by MGI
Official Full Name
AHA1, activator of heat shock protein ATPase 2provided by MGI
Primary source
MGI:MGI:1916133
See related
Ensembl:ENSMUSG00000020288 AllianceGenome:MGI:1916133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ATPase activator activity. Predicted to be involved in protein folding. Predicted to be active in cytosol. Is expressed in brain; cerebral cortex ventricular layer; and cortical plate. Orthologous to human AHSA2P (activator of HSP90 ATPase homolog 2, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 24.7), CNS E14 (RPKM 23.2) and 26 other tissues See more
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Genomic context

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See Ahsa2 in Genome Data Viewer
Location:
11 A3.2; 11 14.32 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23437882..23448045, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23487882..23498045, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene exportin 1 Neighboring gene ubiquitin specific peptidase 34 Neighboring gene STARR-seq mESC enhancer starr_28911 Neighboring gene RIKEN cDNA 1700030C12 gene Neighboring gene STARR-positive B cell enhancer ABC_E9818 Neighboring gene predicted gene, 22753 Neighboring gene STARR-seq mESC enhancer starr_28912 Neighboring gene RIKEN cDNA 1700093K21 gene Neighboring gene STARR-seq mESC enhancer starr_28914 Neighboring gene STARR-seq mESC enhancer starr_28915 Neighboring gene STARR-seq mESC enhancer starr_28916 Neighboring gene STARR-seq mESC enhancer starr_28917 Neighboring gene selenoprotein K, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus. Li X, et al. Antioxid Redox Signal, 2014 Oct 20. PMID 24483844, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36626, 1110064P04Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
activator of 90 kDa heat shock protein ATPase homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290654.1 → NP_001277583.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001277583.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream AUG, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK034661, AK137116, CJ147821
    Consensus CDS
    CCDS70149.1
    UniProtKB/TrEMBL
    F6S1R2
    Related
    ENSMUSP00000105166.2, ENSMUST00000109539.8
    Conserved Domains (2) summary
    cd08892
    Location:154 → 277
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    smart01000
    Location:1 → 110
    Aha1_N; Activator of Hsp90 ATPase, N-terminal

  2. NM_001290655.1 → NP_001277584.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK034661, AK137116, AL672049, CJ147821
    UniProtKB/Swiss-Prot
    Q8N9S3
    Conserved Domains (2) summary
    smart01000
    Location:29 → 158
    Aha1_N; Activator of Hsp90 ATPase, N-terminal
    cl14643
    Location:202 → 274
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  3. NM_172391.4 → NP_765979.3  activator of 90 kDa heat shock protein ATPase homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_765979.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK034661, AK137116, CJ147821
    Consensus CDS
    CCDS24476.1
    UniProtKB/Swiss-Prot
    Q0P626, Q6P3F2, Q7TMW7, Q8CBI4, Q8N9S3
    UniProtKB/TrEMBL
    F6S1R2
    Related
    ENSMUSP00000020529.7, ENSMUST00000020529.13
    Conserved Domains (3) summary
    cd08892
    Location:202 → 325
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    smart01000
    Location:29 → 158
    Aha1_N; Activator of Hsp90 ATPase, N-terminal
    COG5580
    Location:20 → 321
    COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    23437882..23448045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246029.2 → XP_030101889.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X3

    Conserved Domains (1) summary
    cd08892
    Location:40 → 163
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins

  2. XM_030246028.2 → XP_030101888.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X1

    Conserved Domains (2) summary
    smart01000
    Location:1 → 110
    Aha1_N; Activator of Hsp90 ATPase, N-terminal
    cl14643
    Location:154 → 226
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  3. XM_011243722.3 → XP_011242024.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_011242024.1

    Conserved Domains (1) summary
    smart01000
    Location:29 → 157
    Aha1_N; Activator of Hsp90 ATPase, N-terminal

RNA

  1. XR_003949450.2 RNA Sequence

  2. XR_003949448.1 RNA Sequence

  3. XR_003949449.2 RNA Sequence

  4. XR_004936969.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N9S3.2 GenPept UniProtKB/Swiss-Prot:Q8N9S3

Gene LinkOut

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