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Slc26a11 solute carrier family 26, member 11 [ Mus musculus (house mouse) ]

Gene ID: 268512, updated on 27-Nov-2024

Summary

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Official Symbol
Slc26a11provided by MGI
Official Full Name
solute carrier family 26, member 11provided by MGI
Primary source
MGI:MGI:2444589
See related
Ensembl:ENSMUSG00000039908 AllianceGenome:MGI:2444589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KBAT; F630021I08Rik
Summary
Enables chloride channel activity and chloride:bicarbonate antiporter activity. Predicted to be involved in chloride transmembrane transport; oxalate transport; and sulfate transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in forelimb bud. Orthologous to human SLC26A11 (solute carrier family 26 member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen adult (RPKM 5.2), adrenal adult (RPKM 4.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc26a11 in Genome Data Viewer
Location:
11 E2; 11 83.36 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119246328..119271902)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119355509..119381076)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7111 Neighboring gene eukaryotic translation initiation factor 4A3 Neighboring gene caspase recruitment domain family, member 14 Neighboring gene N-sulfoglucosamine sulfohydrolase (sulfamidase) Neighboring gene STARR-seq mESC enhancer starr_31317 Neighboring gene microRNA 1932 Neighboring gene ring finger protein 213 Neighboring gene STARR-positive B cell enhancer ABC_E3043 Neighboring gene RIKEN cDNA A930037H05 gene Neighboring gene STARR-positive B cell enhancer ABC_E7112

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H⁺-ATPase. Rahmati N, et al. Pflugers Arch, 2013 Nov. PMID 23733100
  2. SLC26A11 (KBAT) in Purkinje Cells Is Critical for Inhibitory Transmission and Contributes to Locomotor Coordination. Rahmati N, et al. eNeuro, 2016 May-Jun. PMID 27390771, Free PMC Article
  3. Slc26a11, a chloride transporter, localizes with the vacuolar H(+)-ATPase of A-intercalated cells of the kidney. Xu J, et al. Kidney Int, 2011 Nov. PMID 21716257
  4. Placental, renal, and ileal sulfate transporter gene expression in mouse gestation. Dawson PA, et al. Biol Reprod, 2012 Aug. PMID 22674389
  5. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chloride:bicarbonate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic anion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in oxalate transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sulfate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfate transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sodium-independent sulfate anion transporter
Names
anion exchanger Slc26a11
kidney brain anion transporter
novel sulfate transporter protein (Slc26a11)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178743.3 → NP_848858.2  sodium-independent sulfate anion transporter

    See identical proteins and their annotated locations for NP_848858.2

    Status: VALIDATED

    Source sequence(s)
    AF345196, AK052202, AL645911
    Consensus CDS
    CCDS25717.1
    UniProtKB/Swiss-Prot
    B2RQF3, Q80ZD3, Q8BTP1, Q8BWL3, Q8CHW8
    Related
    ENSMUSP00000050999.8, ENSMUST00000050880.8
    Conserved Domains (1) summary
    TIGR00815
    Location:18 → 542
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119246328..119271902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156722.1 → XP_036012615.1  sodium-independent sulfate anion transporter isoform X2

    UniProtKB/Swiss-Prot
    B2RQF3, Q80ZD3, Q8BTP1, Q8BWL3, Q8CHW8
    Conserved Domains (1) summary
    TIGR00815
    Location:18 → 542
    sulP; high affinity sulphate transporter 1

  2. XM_006533420.4 → XP_006533483.1  sodium-independent sulfate anion transporter isoform X4

    Conserved Domains (1) summary
    COG0659
    Location:101 → 419
    SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]

  3. XM_006533419.5 → XP_006533482.1  sodium-independent sulfate anion transporter isoform X3

    Conserved Domains (1) summary
    TIGR00815
    Location:18 → 451
    sulP; high affinity sulphate transporter 1

  4. XM_006533421.3 → XP_006533484.1  sodium-independent sulfate anion transporter isoform X5

    See identical proteins and their annotated locations for XP_006533484.1

    UniProtKB/Swiss-Prot
    Q80ZD3
    Conserved Domains (1) summary
    TIGR00815
    Location:96 → 370
    sulP; high affinity sulphate transporter 1

  5. XM_006533418.3 → XP_006533481.1  sodium-independent sulfate anion transporter isoform X1

    Conserved Domains (1) summary
    TIGR00815
    Location:35 → 559
    sulP; high affinity sulphate transporter 1

RNA

  1. XR_004936974.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZD3.2 GenPept UniProtKB/Swiss-Prot:Q80ZD3

Gene LinkOut

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