Ctsj cathepsin J [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctsjprovided by MGI
Official Full Name: cathepsin Jprovided by MGI
Primary source: MGI:MGI:1349426
See related: Ensembl:ENSMUSG00000055298 AllianceGenome:MGI:1349426
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CATP; Ctsp; CatRLP
Summary: Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including brain; extraembryonic component; and placenta. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward placenta adult (RPKM 1014.2) See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13 B2; 13 32.62 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (61147993..61153739, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (61000179..61005925, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results show that cathepsin P, in contrast to other mammalian cathepsins, has a restricted catalytic specificity.
Title: Defining the substrate specificity of mouse cathepsin P.
Characterization of the catalytic properties of cathepsin P.
Title: Expression and characterization of cathepsin P.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

Go to the top of the page Help

Markers

Ctsj (e-PCR), detects polymorphism
- UniSTS:275684

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: cathepsin J

Names: Cat P; cathepsin L-related protein; cathepsin P; catlrp-p; gene/Cathepsin L-related protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356291.1 → NP_001343220.1 cathepsin J isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AK005526

Consensus CDS

CCDS88467.1

UniProtKB/Swiss-Prot

Q564D9, Q91XK6, Q9R014, Q9WV51

Related

ENSMUSP00000153389.2, ENSMUST00000224224.2

Conserved Domains (2) summary

smart00848
Location:29 → 87

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:114 → 331

Peptidase_C1; Papain family cysteine protease
NM_012007.2 → NP_036137.1 cathepsin J isoform 2 precursor

See identical proteins and their annotated locations for NP_036137.1

Status: VALIDATED

Source sequence(s)

AF136272, AK005526, AK131661

Consensus CDS

CCDS49291.1

UniProtKB/TrEMBL

A0A0R4J0V8

Related

ENSMUSP00000071457.5, ENSMUST00000071526.6

Conserved Domains (2) summary

smart00848
Location:29 → 86

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:113 → 330

Peptidase_C1; Papain family cysteine protease