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Eif2s3x eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked [ Mus musculus (house mouse) ]

Gene ID: 26905, updated on 27-Nov-2024

Summary

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Official Symbol
Eif2s3xprovided by MGI
Official Full Name
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linkedprovided by MGI
Primary source
MGI:MGI:1349431
See related
Ensembl:ENSMUSG00000035150 AllianceGenome:MGI:1349431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif-2gx; eIF-2-gamma X
Summary
Predicted to enable methionyl-initiator methionine tRNA binding activity and translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex. Is active in synapse. Is expressed in several structures, including brain; diaphragm; embryo mesenchyme; liver; and skeletal musculature. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to several human genes including EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 48.5), placenta adult (RPKM 48.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Eif2s3x in Genome Data Viewer
Location:
X C3; X 41.52 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93232315..93256257, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94188709..94212651, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 6987 Neighboring gene STARR-seq mESC enhancer starr_47554 Neighboring gene zinc finger protein X-linked Neighboring gene STARR-seq mESC enhancer starr_47555 Neighboring gene predicted gene, 46691 Neighboring gene STARR-seq mESC enhancer starr_47557 Neighboring gene STARR-seq mESC enhancer starr_47559 Neighboring gene STARR-positive B cell enhancer ABC_E8763 Neighboring gene kelch-like 15 Neighboring gene microRNA 7673 Neighboring gene predicted gene 5400

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain. Xu J, et al. Gene Expr Patterns, 2006 Jan. PMID 16325480
  2. Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB. Young-Baird SK, et al. Mol Cell, 2020 Feb 20. PMID 31836389, Free PMC Article
  3. Wnt pathway anomalies in developing amygdalae of Turner syndrome-like mice. Raefski AS, et al. J Mol Neurosci, 2007. PMID 17873295
  4. Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Ehrmann IE, et al. Hum Mol Genet, 1998 Oct. PMID 9736774
  5. Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome. Sandstedt SA, et al. Genome Res, 2004 Feb. PMID 14762062, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Eif2s3x is expressed higher in females than in males in developing and adult brains as well as adult liver
    Title: Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables membrane scission GTPase motor activity IEA
Inferred from Electronic Annotation
more info
  
enables methionyl-initiator methionine tRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation factor activity, RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables translation factor activity, RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 2 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 2 subunit 3, X-linked
Names
eIF2-gamma X
eukaryotic translation initiation factor 2 subunit gamma, X-linked
NP_036140.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012010.3 → NP_036140.1  eukaryotic translation initiation factor 2 subunit 3, X-linked

    See identical proteins and their annotated locations for NP_036140.1

    Status: VALIDATED

    Source sequence(s)
    AL646049, AL646092
    Consensus CDS
    CCDS30277.1
    UniProtKB/Swiss-Prot
    Q9Z0N1
    UniProtKB/TrEMBL
    Q3TML6, Q3UIJ2
    Related
    ENSMUSP00000059395.9, ENSMUST00000050328.15
    Conserved Domains (1) summary
    PTZ00327
    Location:13 → 466
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    93232315..93256257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0N1.2 GenPept UniProtKB/Swiss-Prot:Q9Z0N1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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