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Fam171a1 family with sequence similarity 171, member A1 [ Mus musculus (house mouse) ]

Gene ID: 269233, updated on 27-Nov-2024

Summary

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Official Symbol
Fam171a1provided by MGI
Official Full Name
family with sequence similarity 171, member A1provided by MGI
Primary source
MGI:MGI:2442917
See related
Ensembl:ENSMUSG00000050530 AllianceGenome:MGI:2442917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9630050M13Rik
Summary
Predicted to be involved in regulation of cell shape and stress fiber assembly. Predicted to be active in plasma membrane. Is expressed in glossopharyngeal ganglion; medulla oblongata basal plate mantle layer; trigeminal ganglion; and trigeminal nerve. Orthologous to human FAM171A1 (family with sequence similarity 171 member A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 16.1), lung adult (RPKM 15.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Fam171a1 in Genome Data Viewer
Location:
2 A1; 2 1.73 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3115261..3228843)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3114224..3227806)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03510 Neighboring gene predicted gene, 54098 Neighboring gene STARR-seq mESC enhancer starr_03511 Neighboring gene predicted gene, 22005 Neighboring gene N-myristoyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E999 Neighboring gene ribonuclease P/MRP 38 subunit Neighboring gene acyl-Coenzyme A binding domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein FAM171A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081161.2 → NP_001074630.1  protein FAM171A1 isoform 1

    See identical proteins and their annotated locations for NP_001074630.1

    Status: VALIDATED

    Source sequence(s)
    AL928883
    Consensus CDS
    CCDS38036.1
    UniProtKB/TrEMBL
    A2ATK9
    Related
    ENSMUSP00000110751.3, ENSMUST00000115099.9
    Conserved Domains (1) summary
    pfam10577
    Location:34 → 890
    UPF0560; uncharacterized protein family UPF0560

  2. NM_001310434.1 → NP_001297363.1  protein FAM171A1 isoform 2

    See identical proteins and their annotated locations for NP_001297363.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' most exon which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA030185, AK036270, AL928883
    Consensus CDS
    CCDS79727.1
    UniProtKB/TrEMBL
    A2ATL1
    Related
    ENSMUSP00000072724.6, ENSMUST00000072955.12
    Conserved Domains (1) summary
    pfam10577
    Location:1 → 765
    UPF0560; uncharacterized protein family UPF0560

  3. NM_001347067.2 → NP_001333996.1  protein FAM171A1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK077831, AL928883
    Consensus CDS
    CCDS84464.1
    UniProtKB/TrEMBL
    A2ATL0
    Related
    ENSMUSP00000053619.7, ENSMUST00000062934.7

  4. NM_001361386.1 → NP_001348315.1  protein FAM171A1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK032237, AL928883, BC048735, CB525292
    Consensus CDS
    CCDS89424.1
    UniProtKB/TrEMBL
    A2ATK8
    Related
    ENSMUSP00000089086.5, ENSMUST00000091505.11
    Conserved Domains (1) summary
    pfam10577
    Location:34 → 292
    UPF0560; Uncharacterized protein family UPF0560

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    3115261..3228843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497479.3 → XP_006497542.1  protein FAM171A1 isoform X2

    Conserved Domains (1) summary
    pfam10577
    Location:34 → 831
    UPF0560; Uncharacterized protein family UPF0560

  2. XM_006497478.3 → XP_006497541.1  protein FAM171A1 isoform X1

    Conserved Domains (1) summary
    pfam10577
    Location:34 → 859
    UPF0560; Uncharacterized protein family UPF0560

  3. XM_036162236.1 → XP_036018129.1  protein FAM171A1 isoform X3

    Conserved Domains (1) summary
    pfam10577
    Location:35 → 532
    UPF0560; Uncharacterized protein family UPF0560

  4. XM_030251634.2 → XP_030107494.1  protein FAM171A1 isoform X3

    Conserved Domains (1) summary
    pfam10577
    Location:35 → 532
    UPF0560; Uncharacterized protein family UPF0560
Nucleotide Protein Strain
Heading Accession and Version

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