Rab39 RAB39, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab39provided by MGI
Official Full Name: RAB39, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:2442855
See related: Ensembl:ENSMUSG00000055069 AllianceGenome:MGI:2442855
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rab39a; C230094F14Rik
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in phagosome acidification and phagosome-lysosome fusion. Predicted to be located in phagocytic vesicle. Is expressed in brain; brainstem; eye; and testis. Orthologous to human RAB39A (RAB39A, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 29.12 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (53595410..53617532, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (53684110..53706232, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that Rab39a negatively regulates the LPS-induced autophagy in macrophages
Title: Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages.
Findings indicate that UACA functions as a Rab39A effector in the retinoic acid-induced differentiation of Neuro2A cells.
Title: Small GTPase Rab39A interacts with UACA and regulates the retinoic acid-induced neurite morphology of Neuro2A cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in phagosome acidification	ISO Inferred from Sequence Orthology more info
involved_in phagosome acidification	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagosome-lysosome fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagosome-lysosome fusion	ISO Inferred from Sequence Orthology more info
involved_in phagosome-lysosome fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein Rab-39A

Names: rab-39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175562.3 → NP_780771.1 ras-related protein Rab-39A

See identical proteins and their annotated locations for NP_780771.1

Status: PROVISIONAL

Source sequence(s)

AC158384

Consensus CDS

CCDS23185.1

UniProtKB/Swiss-Prot

Q8BHD0

UniProtKB/TrEMBL

Q0PD15

Related

ENSMUSP00000063804.4, ENSMUST00000068449.4

Conserved Domains (2) summary

cd04111
Location:7 → 217

Rab39; Rab GTPase family 39 (Rab39)

smart00175
Location:9 → 176

RAB; Rab subfamily of small GTPases