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BRPF3 bromodomain and PHD finger containing 3 [ Homo sapiens (human) ]

Gene ID: 27154, updated on 27-Nov-2024

Summary

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Official Symbol
BRPF3provided by HGNC
Official Full Name
bromodomain and PHD finger containing 3provided by HGNC
Primary source
HGNC:HGNC:14256
See related
Ensembl:ENSG00000096070 MIM:616856; AllianceGenome:HGNC:14256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Contributes to histone acetyltransferase activity. Involved in positive regulation of DNA replication. Located in nucleus. Part of MOZ/MORF histone acetyltransferase complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 15.9), kidney (RPKM 10.5) and 25 other tissues See more
Orthologs
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Genomic context

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See BRPF3 in Genome Data Viewer
Location:
6p21.31
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36196744..36232790)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36017037..36053081)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36164521..36200567)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 14 Neighboring gene NUDT5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36098441-36099044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36106471-36106971 Neighboring gene mitogen-activated protein kinase 13 Neighboring gene BRPF3 antisense RNA 1 Neighboring gene MPRA-validated peak5782 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36203227-36203772 Neighboring gene Sharpr-MPRA regulatory region 10771 Neighboring gene uncharacterized LOC105375036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36235945-36236531 Neighboring gene patatin like phospholipase domain containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:36253718-36253903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36269917-36270417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24423 Neighboring gene BCL2 interacting protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation. Feng Y, et al. EMBO J, 2016 Jan 18. PMID 26620551, Free PMC Article
  2. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Ullah M, et al. Mol Cell Biol, 2008 Nov. PMID 18794358, Free PMC Article
  3. KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation. Ohzeki J, et al. Dev Cell, 2016 Jun 6. PMID 27270040, Free PMC Article
  4. Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Gogstad GO, et al. Biochim Biophys Acta, 1981 Sep 29. PMID 6457647
  5. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Coppinger JA, et al. Blood, 2004 Mar 15. PMID 14630798

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H4K12 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H4K5 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H4K8 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of developmental process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of hemopoiesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MOZ/MORF histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MOZ/MORF histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
bromodomain and PHD finger-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015695.3 → NP_056510.2  bromodomain and PHD finger-containing protein 3

    See identical proteins and their annotated locations for NP_056510.2

    Status: VALIDATED

    Source sequence(s)
    AB033112, BC039615, Z84485
    Consensus CDS
    CCDS34437.1
    UniProtKB/Swiss-Prot
    A6ND56, A6NJE2, B7ZLN5, E7EX85, Q17RB6, Q5R3K8, Q9ULD4
    UniProtKB/TrEMBL
    E9PI60
    Related
    ENSP00000350267.6, ENST00000357641.10
    Conserved Domains (6) summary
    cd05839
    Location:1074 → 1189
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:593 → 690
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15572
    Location:212 → 265
    PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
    cd15703
    Location:269 → 386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    pfam10513
    Location:48 → 194
    EPL1; Enhancer of polycomb-like
    pfam15429
    Location:848 → 972
    DUF4628; Domain of unknown function (DUF4628)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    36196744..36232790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514490.2 → XP_011512792.1  bromodomain and PHD finger-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    E9PI60
    Conserved Domains (6) summary
    cd05512
    Location:593 → 690
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15572
    Location:212 → 265
    PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
    cd15703
    Location:269 → 386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    pfam10513
    Location:48 → 194
    EPL1; Enhancer of polycomb-like
    pfam15429
    Location:848 → 972
    DUF4628; Domain of unknown function (DUF4628)
    cl02554
    Location:1074 → 1144
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  2. XM_047418649.1 → XP_047274605.1  bromodomain and PHD finger-containing protein 3 isoform X6

    UniProtKB/Swiss-Prot
    A6ND56, A6NJE2, B7ZLN5, E7EX85, Q17RB6, Q5R3K8, Q9ULD4
    Related
    ENSP00000436504.1, ENST00000534400.5

  3. XM_011514491.2 → XP_011512793.1  bromodomain and PHD finger-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    E9PI60
    Conserved Domains (7) summary
    cd05512
    Location:593 → 690
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5076
    Location:528 → 743
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    cd15572
    Location:212 → 265
    PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
    cd15703
    Location:269 → 386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    pfam10513
    Location:48 → 194
    EPL1; Enhancer of polycomb-like
    pfam15429
    Location:848 → 972
    DUF4628; Domain of unknown function (DUF4628)
    cl02554
    Location:1074 → 1095
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  4. XM_047418650.1 → XP_047274606.1  bromodomain and PHD finger-containing protein 3 isoform X3

  5. XM_011514492.2 → XP_011512794.1  bromodomain and PHD finger-containing protein 3 isoform X4

    UniProtKB/TrEMBL
    E9PSF3
    Conserved Domains (4) summary
    cd05512
    Location:593 → 690
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15572
    Location:212 → 265
    PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
    cd15703
    Location:269 → 386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    pfam10513
    Location:48 → 194
    EPL1; Enhancer of polycomb-like

  6. XM_047418651.1 → XP_047274607.1  bromodomain and PHD finger-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    F6XDC4
    Related
    ENSP00000437087.1, ENST00000532330.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    36017037..36053081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355175.1 → XP_054211150.1  bromodomain and PHD finger-containing protein 3 isoform X7

  2. XM_054355176.1 → XP_054211151.1  bromodomain and PHD finger-containing protein 3 isoform X1

  3. XM_054355177.1 → XP_054211152.1  bromodomain and PHD finger-containing protein 3 isoform X2

  4. XM_054355178.1 → XP_054211153.1  bromodomain and PHD finger-containing protein 3 isoform X3

  5. XM_054355179.1 → XP_054211154.1  bromodomain and PHD finger-containing protein 3 isoform X4

  6. XM_054355180.1 → XP_054211155.1  bromodomain and PHD finger-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    F6XDC4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULD4.2 GenPept UniProtKB/Swiss-Prot:Q9ULD4

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