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Gins2 GINS complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 272551, updated on 27-Nov-2024

Summary

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Official Symbol
Gins2provided by MGI
Official Full Name
GINS complex subunit 2provided by MGI
Primary source
MGI:MGI:1921019
See related
Ensembl:ENSMUSG00000031821 AllianceGenome:MGI:1921019
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pfs2; Psf2; 2210013I18Rik; 4833427B12Rik
Summary
Predicted to be involved in DNA unwinding involved in DNA replication and double-strand break repair via break-induced replication. Predicted to be located in nucleus. Predicted to be part of CMG complex and GINS complex. Is expressed in cerebral cortex subventricular zone; cortical plate; and heart. Orthologous to human GINS2 (GINS complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 32.6), liver E14.5 (RPKM 25.4) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Gins2 in Genome Data Viewer
Location:
8 E1; 8 69.86 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121308005..121315814, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (120581266..120589075, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene genetic suppressor element 1, coiled-coil protein Neighboring gene RIKEN cDNA 1700016A09 gene Neighboring gene STARR-positive B cell enhancer ABC_E9746 Neighboring gene STARR-positive B cell enhancer ABC_E362 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123063389-123063498 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123067513-123067836 Neighboring gene microRNA 7687 Neighboring gene STARR-positive B cell enhancer ABC_E246 Neighboring gene RIKEN cDNA 1190005I06 gene Neighboring gene predicted gene 10614 Neighboring gene STARR-seq mESC enhancer starr_22909 Neighboring gene predicted gene, 27021 Neighboring gene predicted gene, 33075

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GINS complex subunit 2 (GINS2) plays a protective role in alcohol-induced brain injury. Liu C, et al. Artif Cells Nanomed Biotechnol, 2019 Dec. PMID 30513217
  2. A key role for the GINS complex at DNA replication forks. Labib K, et al. Trends Cell Biol, 2007 Jun. PMID 17467990
  3. CUL2(LRR1) , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle. Villa F, et al. EMBO Rep, 2021 Mar 3. PMID 33590678, Free PMC Article
  4. Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis. Kang YH, et al. Proc Natl Acad Sci U S A, 2012 Apr 17. PMID 22474384, Free PMC Article
  5. The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. Westendorp B, et al. FASEB J, 2012 Jun. PMID 22403008

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GINS2 plays a protective role in alcohol-induced brain injury
    Title: GINS complex subunit 2 (GINS2) plays a protective role in alcohol-induced brain injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA unwinding involved in DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CMG complex ISO
Inferred from Sequence Orthology
more info
  
part_of CMG complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GINS complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
DNA replication complex GINS protein PSF2
Names
GINS complex subunit 2 (Psf2 homolog)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178856.1 → NP_849187.1  DNA replication complex GINS protein PSF2

    See identical proteins and their annotated locations for NP_849187.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082565
    Consensus CDS
    CCDS40496.1
    UniProtKB/Swiss-Prot
    Q8BMT2, Q9D600
    Related
    ENSMUSP00000034278.6, ENSMUST00000034278.6
    Conserved Domains (1) summary
    cd11712
    Location:55 → 174
    GINS_A_psf2; Alpha-helical domain of GINS complex protein Psf2 (partner of Sld5 2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    121308005..121315814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D600.1 GenPept UniProtKB/Swiss-Prot:Q9D600

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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