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Golga5 golgin A5 [ Mus musculus (house mouse) ]

Gene ID: 27277, updated on 27-Nov-2024

Summary

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Official Symbol
Golga5provided by MGI
Official Full Name
golgin A5provided by MGI
Primary source
MGI:MGI:1351475
See related
Ensembl:ENSMUSG00000021192 AllianceGenome:MGI:1351475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ret-II
Summary
Predicted to enable protein homodimerization activity; protein-macromolecule adaptor activity; and small GTPase binding activity. Predicted to be involved in Golgi organization and retrograde transport, vesicle recycling within Golgi. Located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; limb bud; liver; and spleen. Orthologous to human GOLGA5 (golgin A5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 11.9), testis adult (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Golga5 in Genome Data Viewer
Location:
12 E; 12 51.51 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102435372..102464274)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102469109..102498015)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33096 Neighboring gene legumain Neighboring gene STARR-positive B cell enhancer ABC_E1862 Neighboring gene STARR-positive B cell enhancer ABC_E7170 Neighboring gene STARR-positive B cell enhancer ABC_E3066 Neighboring gene STARR-positive B cell enhancer ABC_E9150 Neighboring gene STARR-positive B cell enhancer ABC_E7171 Neighboring gene predicted gene, 30198 Neighboring gene STARR-seq mESC enhancer starr_33098 Neighboring gene STARR-seq mESC enhancer starr_33099 Neighboring gene chromogranin A Neighboring gene inositol 1,3,4-triphosphate 5/6 kinase Neighboring gene microRNA 1936

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genes induced by growth arrest in a pancreatic beta cell line: identification by analysis of cDNA arrays. Zimmer Y, et al. FEBS Lett, 1999 Aug 20. PMID 10486565
  2. Golga5 is dispensable for mouse embryonic development and postnatal survival. McGee LJ, et al. Genesis, 2017 Jul. PMID 28509431, Free PMC Article
  3. Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase. Jiang Q, et al. Neurobiol Aging, 2014 Jun. PMID 24368089
  4. Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain. Bascom RA, et al. J Biol Chem, 1999 Jan 29. PMID 9915833
  5. Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Mulder J, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18562289, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Golga5 is not required for mouse embryonic development, postnatal survival, or fertility.
    Title: Golga5 is dispensable for mouse embryonic development and postnatal survival.
  2. Its deficit is associated with Golgi fragmentation that induces tau hyperphosphorylation.
    Title: Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102087

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in Golgi vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi vesicle transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde transport, vesicle recycling within Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, vesicle recycling within Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in COPI-coated vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi cis cisterna ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi cisterna IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi trans cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network IEA
Inferred from Electronic Annotation
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
golgin subfamily A member 5
Names
golgi autoantigen golgin subfamily a5
golgi autoantigen, golgin subfamily a, 5
golgin-84
protein Sumiko

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199004.1 → NP_001185933.1  golgin subfamily A member 5

    See identical proteins and their annotated locations for NP_001185933.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK138455, BC086782
    Consensus CDS
    CCDS36526.1
    UniProtKB/Swiss-Prot
    O88317, Q3TGE7, Q3U6S5, Q3UUF9, Q9QYE6
    Related
    ENSMUSP00000137305.2, ENSMUST00000179218.9
    Conserved Domains (2) summary
    COG1196
    Location:231 → 565
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09787
    Location:418 → 723
    Golgin_A5; Golgin subfamily A member 5

  2. NM_013747.4 → NP_038775.1  golgin subfamily A member 5

    See identical proteins and their annotated locations for NP_038775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC086782
    Consensus CDS
    CCDS36526.1
    UniProtKB/Swiss-Prot
    O88317, Q3TGE7, Q3U6S5, Q3UUF9, Q9QYE6
    Related
    ENSMUSP00000021609.9, ENSMUST00000021609.10
    Conserved Domains (2) summary
    COG1196
    Location:231 → 565
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09787
    Location:418 → 723
    Golgin_A5; Golgin subfamily A member 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    102435372..102464274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515935.5 → XP_006515998.1  golgin subfamily A member 5 isoform X1

    See identical proteins and their annotated locations for XP_006515998.1

    UniProtKB/Swiss-Prot
    O88317, Q3TGE7, Q3U6S5, Q3UUF9, Q9QYE6
    Conserved Domains (2) summary
    COG1196
    Location:231 → 565
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09787
    Location:418 → 723
    Golgin_A5; Golgin subfamily A member 5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYE6.2 GenPept UniProtKB/Swiss-Prot:Q9QYE6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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