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TP53TG5 TP53 target 5 [ Homo sapiens (human) ]

Gene ID: 27296, updated on 27-Nov-2024

Summary

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Official Symbol
TP53TG5provided by HGNC
Official Full Name
TP53 target 5provided by HGNC
Primary source
HGNC:HGNC:15856
See related
Ensembl:ENSG00000124251 MIM:617316; AllianceGenome:HGNC:15856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLG01; C20orf10
Summary
Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 14.6) and brain (RPKM 1.1) See more
Orthologs
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Genomic context

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See TP53TG5 in Genome Data Viewer
Location:
20q13.12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45372557..45378325, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47108428..47114194, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44001197..44006965, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene syndecan 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:43971073-43971967 Neighboring gene uncharacterized LOC124904914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17947 Neighboring gene SYS1-DBNDD2 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17949 Neighboring gene SYS1 golgi trafficking protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17950 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 10 Neighboring gene uncharacterized LOC107985404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44035517-44036066 Neighboring gene dysbindin domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a novel TP53-inducible gene, TP53TG5, which suppresses growth and shows cell cycle-dependent transition of expression. Isaka S, et al. Genes Chromosomes Cancer, 2000 Apr. PMID 10719363
  2. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100
  3. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
  4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  5. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Aregger M, et al. Nat Metab, 2020 Jun. PMID 32694731, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell growth NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
TP53-target gene 5 protein
Names
TP53-inducible gene 5 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014477.3 → NP_055292.1  TP53-target gene 5 protein

    See identical proteins and their annotated locations for NP_055292.1

    Status: VALIDATED

    Source sequence(s)
    AB017802, AL021578, BC036785
    Consensus CDS
    CCDS13352.1
    UniProtKB/Swiss-Prot
    Q9Y2B4
    Related
    ENSP00000361811.3, ENST00000372726.5
    Conserved Domains (1) summary
    pfam15331
    Location:28 → 247
    TP53IP5; Cellular tumor antigen p53-inducible 5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    45372557..45378325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528790.3 → XP_011527092.1  TP53-target gene 5 protein isoform X1

    See identical proteins and their annotated locations for XP_011527092.1

    Conserved Domains (1) summary
    pfam15331
    Location:12 → 231
    TP53IP5; Cellular tumour antigen p53-inducible 5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    47108428..47114194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323364.1 → XP_054179339.1  TP53-target gene 5 protein isoform X1

    UniProtKB/TrEMBL
    B4DHX6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2B4.1 GenPept UniProtKB/Swiss-Prot:Q9Y2B4

Gene LinkOut

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