Yme1l1 YME1-like 1 (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Yme1l1provided by MGI
Official Full Name: YME1-like 1 (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:1351651
See related: Ensembl:ENSMUSG00000026775 AllianceGenome:MGI:1351651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ftsh; FtsH1
Summary: Enables ATP-dependent peptidase activity. Involved in several processes, including mitochondrial protein processing; neuronal stem cell population maintenance; and positive regulation of mitochondrial fusion. Located in mitochondrion. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in optic atrophy 11. Orthologous to human YME1L1 (YME1 like 1 ATPase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in placenta adult (RPKM 18.6), CNS E11.5 (RPKM 15.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 15.24 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (23046517..23089272)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (23155442..23199260)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth.
Title: The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth.
Sirt3 mitigates LPS-induced mitochondrial damage in renal tubular epithelial cells by deacetylating YME1L1.
Title: Sirt3 mitigates LPS-induced mitochondrial damage in renal tubular epithelial cells by deacetylating YME1L1.
Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L.
Title: Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L.
GDF11 enhances therapeutic efficacy of mesenchymal stem cells for myocardial infarction via YME1L-mediated OPA1 processing.
Title: GDF11 enhances therapeutic efficacy of mesenchymal stem cells for myocardial infarction via YME1L-mediated OPA1 processing.
Down-regulation of the mitochondrial i-AAA protease Yme1L induces muscle atrophy via FoxO3a and myostatin activation.
Title: Down-regulation of the mitochondrial i-AAA protease Yme1L induces muscle atrophy via FoxO3a and myostatin activation.
YME1L-deficient mice manifest ocular dysfunction with microphthalmia and cataracts and develop deficiencies in locomotor activity due to specific degeneration of spinal cord axons, which relay proprioceptive signals from the hind limbs to the cerebellum.
Title: Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.
Data suggest that in a mouse model of neonatal hypoxic-ischemic brain injury, the expression of mitochondrial shaping proteins, such as OPA1 and Yme1L, are altered; in vitro and in vivo, OPA1 is cleaved to shorter forms and Yme1L expression is reduced.
Title: Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury.
Constitutive OPA1 cleavage by YME1L and OMA1 at two distinct sites leads to the accumulation of both long and short forms of OPA1 and maintains mitochondrial fusion.
Title: The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP-dependent peptidase activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial protein processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mitochondrial fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in protein hexamerization	IEA Inferred from Electronic Annotation more info
involved_in protein hexamerization	ISO Inferred from Sequence Orthology more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	ISO Inferred from Sequence Orthology more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stem cell division	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-dependent zinc metalloprotease YME1L1

Names: ATP-dependent metalloprotease FtsH1; YME1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013771.5 → NP_038799.1 ATP-dependent zinc metalloprotease YME1L1

See identical proteins and their annotated locations for NP_038799.1

Status: VALIDATED

Source sequence(s)

AF090430, AL928706, BB624412

Consensus CDS

CCDS15728.1

UniProtKB/Swiss-Prot

O88967, Q7TNN5

Related

ENSMUSP00000028117.4, ENSMUST00000028117.4

Conserved Domains (4) summary

TIGR01241
Location:275 → 708

FtsH_fam; ATP-dependent metalloprotease FtsH

pfam00004
Location:317 → 448

AAA; ATPase family associated with various cellular activities (AAA)

pfam01434
Location:528 → 706

Peptidase_M41; Peptidase family M41

cl21455
Location:273 → 337

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases