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Akr1c13 aldo-keto reductase family 1, member C13 [ Mus musculus (house mouse) ]

Gene ID: 27384, updated on 4-Jan-2025

Summary

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Official Symbol
Akr1c13provided by MGI
Official Full Name
aldo-keto reductase family 1, member C13provided by MGI
Primary source
MGI:MGI:1351662
See related
Ensembl:ENSMUSG00000021213 AllianceGenome:MGI:1351662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4014
Summary
Predicted to enable several functions, including ketosteroid monooxygenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and retinal dehydrogenase activity. Predicted to be involved in several processes, including cellular response to jasmonic acid stimulus; glycoside metabolic process; and prostaglandin metabolic process. Predicted to act upstream of or within xenobiotic metabolic process. Predicted to be active in cytosol. Is expressed in gut and liver lobe. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in liver E18 (RPKM 17.2), large intestine adult (RPKM 12.8) and 17 other tissues See more
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Genomic context

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See Akr1c13 in Genome Data Viewer
Location:
13 A1; 13 2.34 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (4241167..4255601)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (4191168..4205604)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C18 Neighboring gene STARR-seq mESC enhancer starr_33499 Neighboring gene STARR-seq mESC enhancer starr_33500 Neighboring gene solute carrier family 23 (nucleobase transporters), member 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33502 Neighboring gene nuclear encoded tRNA lysine 6 (anticodon CTT) Neighboring gene aldo-keto reductase family 1, member C19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread. McFarland AP, et al. mBio, 2018 May 15. PMID 29764944, Free PMC Article
  2. Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State. McFarland AP, et al. Immunity, 2017 Mar 21. PMID 28329705, Free PMC Article
  3. Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis. Endo S, et al. Arch Biochem Biophys, 2007 Nov 1. PMID 17888864
  4. Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach. Ikeda S, et al. FEBS Lett, 1999 Oct 15. PMID 10526179
  5. Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models. Shimizu R, et al. Biochem Biophys Res Commun, 2021 Jan 8. PMID 33348080

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Listeria monocytogenes secretion of c-di-AMP inhibits RECON ( Akr1c13) activity, drives augmented NF-kappaB activation and nitric oxide production, and ultimately enhances intercellular spread.
    Title: RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.
  2. Akr1c13 functions as a cytosolic sensor for bacterial cyclic dinucleotides, shaping inflammatory gene activation
    Title: Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.
  3. analysis of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases.
    Title: Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • KIAA4014

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aldo-keto reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables androsterone dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables bile acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chlordecone reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables ketosteroid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to jasmonic acid stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in daunorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in daunorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in doxorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in doxorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in progesterone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within xenobiotic metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aldo-keto reductase family 1 member C13
Names
aldo-keto reductase AKR1C13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426627.1 → NP_001413556.1  aldo-keto reductase family 1 member C13 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121097, AC122840
    UniProtKB/TrEMBL
    Q54A37

  2. NM_001426630.1 → NP_001413559.1  aldo-keto reductase family 1 member C13 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121097, AC122840
    UniProtKB/TrEMBL
    Q54A37

  3. NM_013778.3 → NP_038806.2  aldo-keto reductase family 1 member C13 isoform 1

    See identical proteins and their annotated locations for NP_038806.2

    Status: VALIDATED

    Source sequence(s)
    AC121097, AC122840
    Consensus CDS
    CCDS26220.1
    UniProtKB/Swiss-Prot
    Q8VC28, Q9D7R9, Q9R0M9
    UniProtKB/TrEMBL
    Q54A37
    Related
    ENSMUSP00000021634.3, ENSMUST00000021634.4
    Conserved Domains (2) summary
    COG0656
    Location:8 → 307
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16 → 297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    4241167..4255601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC28.2 GenPept UniProtKB/Swiss-Prot:Q8VC28

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