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Smtnl2 smoothelin-like 2 [ Mus musculus (house mouse) ]

Gene ID: 276829, updated on 27-Nov-2024

Summary

Official Symbol
Smtnl2provided by MGI
Official Full Name
smoothelin-like 2provided by MGI
Primary source
MGI:MGI:2442764
See related
Ensembl:ENSMUSG00000045667 AllianceGenome:MGI:2442764
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D130058I21Rik
Summary
Predicted to be involved in actin cytoskeleton organization. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Is expressed in several structures, including adipose tissue; femur; heart; lung; and metanephros. Orthologous to human SMTNL2 (smoothelin like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 9.3), mammary gland adult (RPKM 6.8) and 21 other tissues See more
Orthologs
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Genomic context

See Smtnl2 in Genome Data Viewer
Location:
11 B4; 11 44.15 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72279989..72302539, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72389163..72411713, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tektin 1 Neighboring gene predicted gene, 34317 Neighboring gene microRNA 6338 Neighboring gene STARR-seq mESC enhancer starr_29906 Neighboring gene STARR-positive B cell enhancer ABC_E10683 Neighboring gene STARR-positive B cell enhancer ABC_E8422 Neighboring gene gamma-glutamyltransferase 6 Neighboring gene MYB binding protein (P160) 1a Neighboring gene SPNS lysolipid transporter 2, sphingosine-1-phosphate

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177776.3NP_808444.1  smoothelin-like protein 2

    See identical proteins and their annotated locations for NP_808444.1

    Status: PROVISIONAL

    Source sequence(s)
    AL662812
    Consensus CDS
    CCDS24985.1
    UniProtKB/Swiss-Prot
    Q8CI12
    UniProtKB/TrEMBL
    Q5F247
    Related
    ENSMUSP00000059043.7, ENSMUST00000050226.7
    Conserved Domains (2) summary
    cd00014
    Location:349453
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl01090
    Location:5689
    SlyX; SlyX

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72279989..72302539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156740.1XP_036012633.1  smoothelin-like protein 2 isoform X1

    Conserved Domains (1) summary
    cd21261
    Location:244350
    CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2
  2. XM_036156742.1XP_036012635.1  smoothelin-like protein 2 isoform X4

    Conserved Domains (1) summary
    cd21261
    Location:226332
    CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2
  3. XM_006533470.3XP_006533533.1  smoothelin-like protein 2 isoform X5

    Conserved Domains (1) summary
    pfam00307
    Location:220325
    CH; Calponin homology (CH) domain
  4. XM_036156743.1XP_036012636.1  smoothelin-like protein 2 isoform X6

    Conserved Domains (1) summary
    cd21261
    Location:160266
    CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2
  5. XM_036156741.1XP_036012634.1  smoothelin-like protein 2 isoform X3

    Conserved Domains (1) summary
    cd21261
    Location:230336
    CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2
  6. XM_006533469.4XP_006533532.1  smoothelin-like protein 2 isoform X2

    Conserved Domains (1) summary
    pfam00307
    Location:243348
    CH; Calponin homology (CH) domain