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Sp212 Serine-peptidase 212 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768666, updated on 9-Dec-2024

Summary

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Official Symbol
Sp212provided by FlyBase
Official Full Name
Serine-peptidase 212provided by FlyBase
Primary source
FLYBASE:FBgn0053329
Locus tag
Dmel_CG33329
See related
AllianceGenome:FB:FBgn0053329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33329; Dmel\CG33329; ORE-5; SP212
Summary
Predicted to enable serine-type endopeptidase activity. Involved in response to bacterium and response to fungus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Sp212 in Genome Data Viewer
Location:
88A12-88A12; 3-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14222074..14224155, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10047796..10049877, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of unannotated exons of low abundance transcripts in Drosophila melanogaster and cloning of a new serine protease gene upregulated upon injury. Maia RM, et al. BMC Genomics, 2007 Jul 24. PMID 17650329, Free PMC Article
  2. A computational and experimental approach to validating annotations and gene predictions in the Drosophila melanogaster genome. Yandell M, et al. Proc Natl Acad Sci U S A, 2005 Feb 1. PMID 15668397, Free PMC Article
  3. Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat. Napoletano F, et al. EMBO J, 2011 Mar 2. PMID 21278706, Free PMC Article
  4. RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1. Jones CI, et al. Nucleic Acids Res, 2016 Jan 8. PMID 26656493, Free PMC Article
  5. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cloning of a new serine protease gene, SP212, that is upregulated upon injury
    Title: Identification of unannotated exons of low abundance transcripts in Drosophila melanogaster and cloning of a new serine protease gene upregulated upon injury.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to fungus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Serine-peptidase 212
Names
CG33329-PC
Sp212-PC
NP_996209.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14222074..14224155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206487.2 → NP_996209.2  Serine-peptidase 212 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996209.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DN13, Q7KSK1
    Conserved Domains (3) summary
    smart00020
    Location:277 → 511
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:277 → 514
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam16030
    Location:23 → 122
    GD_N; Serine protease gd N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1E5L3 A1E5L3
Q7KSK1 Q7KSK1

Gene LinkOut

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