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Myo95E Myosin 95E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768680, updated on 9-Dec-2024

Summary

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Official Symbol
Myo95Eprovided by FlyBase
Official Full Name
Myosin 95Eprovided by FlyBase
Primary source
FLYBASE:FBgn0039157
Locus tag
Dmel_CG5501
See related
AllianceGenome:FB:FBgn0039157
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
95E; CG31134; CG31135; CG5501; Dm95E; DmAE003746; Dmel\CG5501; myo 95E; Myo5
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization; actin filament-based movement; and endocytosis. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Orthologous to human MYO1A (myosin IA) and MYO1B (myosin IB). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Myo95E in Genome Data Viewer
Location:
95E6-95E6; 3-83 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24154826..24161498, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19980548..19987220, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene p38c MAP kinase Neighboring gene p38a MAP kinase Neighboring gene uncharacterized protein Neighboring gene TBC1 domain family member 7 Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene Adenomatous polyposis coli 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Class I myosins have overlapping and specialized functions in left-right asymmetric development in Drosophila. Okumura T, et al. Genetics, 2015 Apr. PMID 25659376, Free PMC Article
  2. Cell Chirality Drives Left-Right Asymmetric Morphogenesis. Inaki M, et al. Front Cell Dev Biol, 2018. PMID 29666795, Free PMC Article
  3. Molecular to organismal chirality is induced by the conserved myosin 1D. Lebreton G, et al. Science, 2018 Nov 23. PMID 30467170, Free PMC Article
  4. A millennial myosin census. Berg JS, et al. Mol Biol Cell, 2001 Apr. PMID 11294886, Free PMC Article
  5. Identification and phylogenetic analysis of Drosophila melanogaster myosins. Tzolovsky G, et al. Mol Biol Evol, 2002 Jul. PMID 12082124

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin 95E
Names
CG5501-PB
CG5501-PD
CG5501-PE
CG5501-PF
CG5501-PG
CG5501-PJ
Myo95E-PB
Myo95E-PD
Myo95E-PE
Myo95E-PF
Myo95E-PG
Myo95E-PJ
Myosin95E
NP_001027204.2
NP_001027206.1
NP_001027207.1
NP_001027208.1
NP_996278.1
NP_996279.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24154826..24161498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206556.2 → NP_996279.1  myosin 95E, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996279.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4AB26, Q8T6L6
    Conserved Domains (2) summary
    cl22853
    Location:403 → 914
    Motor_domain; Myosin and Kinesin motor domain
    pfam06017
    Location:1062 → 1237
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  2. NM_206555.2 → NP_996278.1  myosin 95E, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996278.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T6L7
    Conserved Domains (2) summary
    cl22853
    Location:403 → 914
    Motor_domain; Myosin and Kinesin motor domain
    pfam06017
    Location:1082 → 1257
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  3. NM_001032035.2 → NP_001027206.1  myosin 95E, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027206.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4AB24
    Conserved Domains (2) summary
    cl22853
    Location:19 → 118
    Motor_domain; Myosin and Kinesin motor domain
    pfam15814
    Location:106 → 207
    FAM199X; Protein family FAM199X

  4. NM_001032037.2 → NP_001027208.1  myosin 95E, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027208.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4AB27
    Conserved Domains (2) summary
    cl22853
    Location:403 → 924
    Motor_domain; Myosin and Kinesin motor domain
    pfam06017
    Location:1092 → 1267
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  5. NM_001032033.2 → NP_001027204.2  myosin 95E, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027204.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4AB26, Q8T6L6
    Conserved Domains (2) summary
    cl22853
    Location:403 → 914
    Motor_domain; Myosin and Kinesin motor domain
    pfam06017
    Location:1062 → 1237
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  6. NM_001032036.2 → NP_001027207.1  myosin 95E, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027207.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4AB24
    Conserved Domains (2) summary
    cl22853
    Location:19 → 118
    Motor_domain; Myosin and Kinesin motor domain
    pfam15814
    Location:106 → 207
    FAM199X; Protein family FAM199X
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4AB24 Q4AB24
Q4AB27 Q4AB27
Q8T6L6 Q8T6L6
Q8T6L7 Q8T6L7
Q961G2 Q961G2

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