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mld molting defective [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768685, updated on 4-Jan-2025

Summary

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Official Symbol
mldprovided by FlyBase
Official Full Name
molting defectiveprovided by FlyBase
Primary source
FLYBASE:FBgn0263490
Locus tag
Dmel_CG34100
See related
AllianceGenome:FB:FBgn0263490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13620; CG31312; CG33343; CG34100; CG9469; Dmel\CG34100; DTS-3; l(3)3[DTS]; L(3)3[DTS]; l(3)DTS3; Mld
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; ecdysone biosynthetic process; and long-term memory. Located in nucleus. Is expressed in several structures, including antennal anlage; antennal primordium; epidermis; germline cell; and head epidermis primordium. Orthologous to several human genes including ZNF107 (zinc finger protein 107); ZNF208 (zinc finger protein 208); and ZNF473 (zinc finger protein 473). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See mld in Genome Data Viewer
Location:
96A9-96A12; 3-85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24585653..24623899)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20411375..20449621)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Repressed by TOR Neighboring gene long non-coding RNA:CR46094 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46095 Neighboring gene Syntaxin 18 Neighboring gene atlastin Neighboring gene wsck Neighboring gene Metallothionein F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The steroid molting hormone Ecdysone regulates sleep in adult Drosophila melanogaster. Ishimoto H, et al. Genetics, 2010 May. PMID 20215472, Free PMC Article
  2. Postembryonic development of the midline glia in the CNS of Drosophila: proliferation, programmed cell death, and endocrine regulation. Awad TA, et al. Dev Biol, 1997 Jul 15. PMID 9242424
  3. Steroid control of longevity in Drosophila melanogaster. Simon AF, et al. Science, 2003 Feb 28. PMID 12610309
  4. Ecdysone signaling regulates the formation of long-term courtship memory in adult Drosophila melanogaster. Ishimoto H, et al. Proc Natl Acad Sci U S A, 2009 Apr 14. PMID 19342482, Free PMC Article
  5. Two distinct mechanisms silence chinmo in Drosophila neuroblasts and neuroepithelial cells to limit their self-renewal. Dillard C, et al. Development, 2018 Jan 25. PMID 29361557

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 24594690-24594874 mobile_element_type = transposon:pogo{}1417

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ecdysone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
molting defective
Names
CG34100-PA
CG34100-PC
CG34100-PD
CG34100-PE
CG34100-PF
DTS-3
defective
dominant temperature-sensitive 3
lethal (3) DTS3
mld-PA
mld-PC
mld-PD
mld-PE
mld-PF
molting

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24585653..24623899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260360.1 → NP_001247289.1  molting defective, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247289.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7S6, D2NUK2
    Conserved Domains (3) summary
    smart00868
    Location:186 → 255
    zf-AD; Zinc-finger associated domain (zf-AD)
    sd00017
    Location:1814 → 1834
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1839 → 1861
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_001043289.2 → NP_001036754.1  molting defective, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036754.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D2NUK2, Q0KI16, Q8IMW5
    Conserved Domains (2) summary
    smart00868
    Location:186 → 255
    zf-AD; Zinc-finger associated domain (zf-AD)
    sd00017
    Location:1756 → 1776
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001260359.1 → NP_001247288.1  molting defective, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247288.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6J3, D2NUK2
    Conserved Domains (3) summary
    smart00868
    Location:186 → 255
    zf-AD; Zinc-finger associated domain (zf-AD)
    sd00017
    Location:1734 → 1754
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1790 → 1812
    zf-C2H2; Zinc finger, C2H2 type

  4. NM_001043290.2 → NP_001036755.2  molting defective, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036755.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D2NUK2, Q0KI16, Q8IMW5
    Conserved Domains (2) summary
    smart00868
    Location:186 → 255
    zf-AD; Zinc-finger associated domain (zf-AD)
    sd00017
    Location:1756 → 1776
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_143016.2 → NP_651273.2  molting defective, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651273.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHB7, D2NUK2
    Conserved Domains (3) summary
    smart00868
    Location:186 → 255
    zf-AD; Zinc-finger associated domain (zf-AD)
    sd00017
    Location:1792 → 1812
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1817 → 1839
    zf-C2H2; Zinc finger, C2H2 type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6J3 A0A0B4K6J3
A0A0B4K7S6 A0A0B4K7S6
A0A0C4DHB7 A0A0C4DHB7
Q8IMW5 Q8IMW5
Q8MSR6 Q8MSR6

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