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AlkB AlkB [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768870, updated on 4-Jan-2025

Summary

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Official Symbol
AlkBprovided by FlyBase
Official Full Name
AlkBprovided by FlyBase
Primary source
FLYBASE:FBgn0065035
Locus tag
Dmel_CG33250
See related
AllianceGenome:FB:FBgn0065035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alkB; BEST:LD02396; CG33250; Dmel\CG33250
Summary
Predicted to enable 2-oxoglutarate-dependent dioxygenase activity; class I DNA-(apurinic or apyrimidinic site) endonuclease activity; and ferrous iron binding activity. Predicted to be involved in oxidative RNA demethylation. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; head mesoderm; posterior endoderm; and trunk mesoderm. Orthologous to human ALKBH1 (alkB homolog 1, histone H2A dioxygenase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See AlkB in Genome Data Viewer
Location:
13F14-13F16; 1-52 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15858134..15859487, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15752167..15753412, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ubiquitin like 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Myb oncogene-like Neighboring gene G protein beta subunit 13F Neighboring gene Glyceraldehyde 3 phosphate dehydrogenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Alpha-ketoglutarate-dependent dioxygenase AlkB is involved in repair from neuronal disorders induced by ultraviolet damage. Wakisaka KT, et al. Neuroreport, 2019 Oct 16. PMID 31503204
  2. The DNA replication-related element-binding factor (DREF) is a transcriptional regulator of the Drosophila myb gene. Sharkov NV, et al. Gene, 2002 Sep 4. PMID 12384302
  3. Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability. Manak JR, et al. Proc Natl Acad Sci U S A, 2002 May 28. PMID 12032301, Free PMC Article
  4. Loss of Drosophila Myb interrupts the progression of chromosome condensation. Manak JR, et al. Nat Cell Biol, 2007 May. PMID 17450131
  5. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Beall EL, et al. Nature, 2002 Dec 19-26. PMID 12490953

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila Alpha-ketoglutarate-dependent dioxygenase AlkB is involved in repair from neuronal disorders induced by ultraviolet damage.
    Title: Drosophila Alpha-ketoglutarate-dependent dioxygenase AlkB is involved in repair from neuronal disorders induced by ultraviolet damage.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables broad specificity oxidative DNA demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables broad specificity oxidative DNA demethylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidative RNA demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in oxidative RNA demethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
AlkB
Names
AlkB-PA
AlkB-PB
CG33250-PA
CG33250-PB
NP_001334682.1
NP_996458.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15858134..15859487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001347758.1 → NP_001334682.1  AlkB, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KUZ2

  2. NM_206735.2 → NP_996458.1  AlkB, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996458.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KUZ2
    Conserved Domains (1) summary
    cl21496
    Location:103 → 262
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KUZ2 Q7KUZ2

Gene LinkOut

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