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CG33298 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768929, updated on 4-Jan-2025

Summary

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Official Symbol
CG33298provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032120
Locus tag
Dmel_CG33298
See related
AllianceGenome:FB:FBgn0032120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13112; CG18419; DmCG33298; Dmel\CG33298
Summary
Enables ATPase-coupled intramembrane lipid transporter activity. Involved in trans-Golgi network membrane organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; dorsal ectoderm; eye disc; hindgut anlage in statu nascendi; and larval central nervous system. Orthologous to several human genes including ATP10A (ATPase phospholipid transporting 10A (putative)) and ATP10D (ATPase phospholipid transporting 10D (putative)). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG33298 in Genome Data Viewer
Location:
30B5-30B10; 2-35 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9495474..9520696)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9495474..9520696)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43769 Neighboring gene GDP dissociation inhibitor Neighboring gene Organic anion transporting polypeptide 30B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functions of phospholipid flippases. Tanaka K, et al. J Biochem, 2011 Feb. PMID 21134888
  2. Modulation of alternative splicing by long-range RNA structures in Drosophila. Raker VA, et al. Nucleic Acids Res, 2009 Aug. PMID 19465384, Free PMC Article
  3. Extreme deformability of insect cell membranes is governed by phospholipid scrambling. Shiomi A, et al. Cell Rep, 2021 Jun 8. PMID 34107250
  4. Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes. Chow CY, et al. Proc Natl Acad Sci U S A, 2013 May 28. PMID 23667151, Free PMC Article
  5. P-type ATPases in Caenorhabditis and Drosophila: implications for evolution of the P-type ATPase subunit families with special reference to the Na,K-ATPase and H,K-ATPase subgroup. Okamura H, et al. J Membr Biol, 2003 Jan 1. PMID 12532273

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 9503225-9503351 mobile_element_type = transposon:INE-1{}6181

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables ATPase-coupled intramembrane lipid transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid translocation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to endoplasmic reticulum stress HMP PubMed 
involved_in trans-Golgi network membrane organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG33298-PA
CG33298-PB
CG33298-PC
CG33298-PD
NP_001162919.1
NP_001162920.1
NP_995665.1
NP_995666.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9495474..9520696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_205944.3 → NP_995666.1  uncharacterized protein Dmel_CG33298, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995666.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTG6
    Conserved Domains (6) summary
    TIGR01652
    Location:250 → 1473
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:302 → 394
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:880 → 965
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:249 → 299
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:1223 → 1468
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:1177 → 1240
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_205943.3 → NP_995665.1  uncharacterized protein Dmel_CG33298, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995665.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTG5
    Conserved Domains (6) summary
    TIGR01652
    Location:250 → 1473
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:302 → 394
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:880 → 965
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:249 → 299
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:1223 → 1468
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:1177 → 1240
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  3. NM_001169448.2 → NP_001162919.1  uncharacterized protein Dmel_CG33298, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162919.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTG5
    Conserved Domains (6) summary
    TIGR01652
    Location:250 → 1473
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:302 → 394
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:880 → 965
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:249 → 299
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:1223 → 1468
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:1177 → 1240
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  4. NM_001169449.2 → NP_001162920.1  uncharacterized protein Dmel_CG33298, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162920.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTG5
    Conserved Domains (6) summary
    TIGR01652
    Location:250 → 1473
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:302 → 394
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:880 → 965
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:249 → 299
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:1223 → 1468
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:1177 → 1240
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KTG5 Q7KTG5
Q7KTG6 Q7KTG6
Q95S66 Q95S66

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