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rho-5 - rhomboid-5

Involved in negative regulation of epidermal growth factor receptor signaling pathway and positive regulation of circadian sleep/wake cycle, wakefulness. Located in endoplasmic reticulum membrane. Is expressed in adult head; embryonic/larval optic lobe; eye disc posterior to the morphogenetic furrow; larval brain; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. Orthologous to human RHBDF1 (rhomboid 5 homolog 1) and RHBDF2 (rhomboid 5 homolog 2). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa