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CG42458 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768945, updated on 4-Jan-2025

Summary

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Official Symbol
CG42458provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0259935
Locus tag
Dmel_CG42458
See related
AllianceGenome:FB:FBgn0259935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg18656; CG18656; CG33277; CG33279; cg42458; Dmel\CG42458; HNPNPC
Old locus tag
Dmel_CG33277; Dmel_CG33279
Summary
Predicted to enable RNA binding activity. Predicted to be involved in RNA stabilization. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in T4 neuron; T5 neuron; medullary tangential neuron Mt1; and transmedullary Y neuron TmY8. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to several human genes including RALYL (RALY RNA binding protein like); HNRNPCL3 (heterogeneous nuclear ribonucleoprotein C like 3); and HNRNPCL4 (heterogeneous nuclear ribonucleoprotein C like 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG42458 in Genome Data Viewer
Location:
65F11-66A1; 3-21 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7423827..7454717)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7416927..7447817)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR33948 Neighboring gene long non-coding RNA:CR44525 Neighboring gene Rac2 Neighboring gene uncharacterized protein Neighboring gene sphinx1 Neighboring gene sphinx2 Neighboring gene uncharacterized protein Neighboring gene pickpocket 26 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 66A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A single cell genomics atlas of the Drosophila larval eye reveals distinct photoreceptor developmental timelines. Bollepogu Raja KK, et al. Nat Commun, 2023 Nov 8. PMID 37938573, Free PMC Article
  2. Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells. Appocher C, et al. Nucleic Acids Res, 2017 Jul 27. PMID 28575377, Free PMC Article
  3. RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM. Ramesh N, et al. Acta Neuropathol Commun, 2020 Aug 18. PMID 32811564, Free PMC Article
  4. Multiple Niche Compartments Orchestrate Stepwise Germline Stem Cell Progeny Differentiation. Tu R, et al. Curr Biol, 2021 Feb 22. PMID 33357404, Free PMC Article
  5. Phenotypic Convergence: Distinct Transcription Factors Regulate Common Terminal Features. Konstantinides N, et al. Cell, 2018 Jul 26. PMID 29909983, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 7439807-7439873 mobile_element_type = transposon:INE-1{}6165

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42458-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7423827..7454717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206288.4 → NP_996010.2  uncharacterized protein Dmel_CG42458 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996010.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A515MFZ2, Q7KU81
    Conserved Domains (2) summary
    COG0724
    Location:11 → 89
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12341
    Location:20 → 87
    RRM_hnRNPC_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein C (hnRNP C)-related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KU81 Q7KU81

Gene LinkOut

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