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GNB1 G protein subunit beta 1 [ Homo sapiens (human) ]

Gene ID: 2782, updated on 27-Nov-2024

Summary

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Official Symbol
GNB1provided by HGNC
Official Full Name
G protein subunit beta 1provided by HGNC
Primary source
HGNC:HGNC:4396
See related
Ensembl:ENSG00000078369 MIM:139380; AllianceGenome:HGNC:4396
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDS; HG2A; MRD42
Summary
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in brain (RPKM 145.4), small intestine (RPKM 87.2) and 25 other tissues See more
Orthologs
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Genomic context

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See GNB1 in Genome Data Viewer
Location:
1p36.33
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1785286..1891087, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1219664..1325475, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1716725..1822526, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S7 pseudogene Neighboring gene solute carrier family 35 member E2A (pseudogene) Neighboring gene uncharacterized LOC112268218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 89 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1684563-1685092 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1691433-1692390 Neighboring gene NAD kinase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1705547-1706048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 90 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 36 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 34 Neighboring gene Sharpr-MPRA regulatory region 14484 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1721473-1721656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 38 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 91 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 39 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1757447-1758350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 41 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1782535-1783035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1783210-1784022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 44 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1798007-1798184 Neighboring gene Sharpr-MPRA regulatory region 3728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1820039-1820538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 92 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 93 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 94 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 95 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 96 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 97 Neighboring gene GNB1 divergent transcript Neighboring gene uncharacterized LOC124903822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 45 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 98

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Refining the phenotype associated with GNB1 mutations: Clinical data on 18 newly identified patients and review of the literature. Hemati P, et al. Am J Med Genet A, 2018 Nov. PMID 30194818
  2. G Protein Subunit β1 Facilitates Influenza A Virus Replication by Promoting the Nuclear Import of PB2. Zheng H, et al. J Virol, 2022 Jun 22. PMID 35604143, Free PMC Article
  3. Association of genetic variations in GNB1 with response to peginterferon plus ribavirin therapy for chronic hepatitis C in a Chinese population in Taiwan. Lim YP, et al. BMC Gastroenterol, 2012 Nov 22. PMID 23171003, Free PMC Article
  4. Guanine nucleotide binding protein β 1: a novel transduction protein with a possible role in human breast cancer. Wazir U, et al. Cancer Genomics Proteomics, 2013 Mar-Apr. PMID 23603342
  5. GNB1 Encephalopathy. Adam MP, et al. , 1993. PMID 32134617

See all (277) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GNB1 and obesity: Evidence for a correlation between haploinsufficiency and syndromic obesity.
    Title: GNB1 and obesity: Evidence for a correlation between haploinsufficiency and syndromic obesity.
  2. Atypical clinical course in two patients with GNB1 variants who developed acute encephalopathy.
    Title: Atypical clinical course in two patients with GNB1 variants who developed acute encephalopathy.
  3. G Protein Subunit beta1 Facilitates Influenza A Virus Replication by Promoting the Nuclear Import of PB2.
    Title: G Protein Subunit β1 Facilitates Influenza A Virus Replication by Promoting the Nuclear Import of PB2.
  4. AFAP1 antisense RNA 1 promotes retinoblastoma progression by sponging microRNA miR-545-3p that targets G protein subunit beta 1.
    Title: AFAP1 antisense RNA 1 promotes retinoblastoma progression by sponging microRNA miR-545-3p that targets G protein subunit beta 1.
  5. Shikonin induces cell autophagy via modulating the microRNA -545-3p/guanine nucleotide binding protein beta polypeptide 1 axis, thereby disrupting cellular carcinogenesis in colon cancer.
    Title: Shikonin induces cell autophagy via modulating the microRNA -545-3p/guanine nucleotide binding protein beta polypeptide 1 axis, thereby disrupting cellular carcinogenesis in colon cancer.
  6. Gbetagamma translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK.
    Title: Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK.
  7. Genotype-phenotype correlation in GNB1-related neurodevelopmental disorder: Potential association of p.Leu95Pro with cleft palate.
    Title: Genotype-phenotype correlation in GNB1-related neurodevelopmental disorder: Potential association of p.Leu95Pro with cleft palate.
  8. In the new cohort of 18 patients, 50% of males had genitourinary anomalies and 61% of patients had gastrointestinal anomalies, suggesting a possible association of these findings with variants in GNB1.
    Title: Refining the phenotype associated with GNB1 mutations: Clinical data on 18 newly identified patients and review of the literature.
  9. Mutation in the GNB1 gene is associated with neurodevelopmental disorder and cutaneous mastocytosis.
    Title: Novel GNB1 de novo mutation in a patient with neurodevelopmental disorder and cutaneous mastocytosis: Clinical report and literature review.
  10. Through analysis of the genomic and proteomic profiles of resistant cells, we identified an acquired mutation in the GNB1 gene, K89M, as the most likely cause of the resistance
    Title: An activating mutation of GNB1 is associated with resistance to tyrosine kinase inhibitors in ETV6-ABL1-positive leukemia.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Acute lymphoid leukemia
MedGen: C0023449 OMIM: 613065 GeneReviews: Not available
Compare labs
Intellectual disability, autosomal dominant 42
MedGen: C4310774 OMIM: 616973 GeneReviews: GNB1 Encephalopathy
Compare labs
Myelodysplastic syndrome
MedGen: C3463824 OMIM: 614286 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2019-01-23)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2019-01-23)

ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of guanine nucleotide binding protein (G protein), beta polypeptide 1 (GNB1) in the nucleoli of Jurkat T-cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of guanine nucleotide binding protein, beta polypeptide 1 (GNB1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Ras protein signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating dopamine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to catecholamine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to prostaglandin E stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of taste IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular vesicle HDA PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane HDA PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in photoreceptor disc membrane TAS
Traceable Author Statement
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Names
beta subunit, signal-transducing proteins GS/GI
guanine nucleotide binding protein (G protein), beta polypeptide 1
heterotrimeric guanine nucleotide-binding protein 2A
testicular tissue protein Li 72
transducin beta chain 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047052.1 RefSeqGene

    Range
    5031..110832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282538.2 → NP_001269467.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 2

    See identical proteins and their annotated locations for NP_001269467.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI092255, AK122949, BC004186, BQ881467
    Consensus CDS
    CCDS72685.1
    UniProtKB/TrEMBL
    B3KVK2, Q71UM6
    Related
    ENSP00000483532.1, ENST00000615252.5
    Conserved Domains (2) summary
    cd00200
    Location:2 → 240
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1 → 41
    7WD40; WD40 repeat [structural motif]

  2. NM_001282539.2 → NP_001269468.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001269468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AI092255, BC004186, BU902364
    Consensus CDS
    CCDS34.1
    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8, A0A2L0WW42
    Related
    ENSP00000481878.1, ENST00000610897.4
    Conserved Domains (2) summary
    cd00200
    Location:48 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]

  3. NM_002074.5 → NP_002065.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 1

    See identical proteins and their annotated locations for NP_002065.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AI092255, BC004186, BQ881467
    Consensus CDS
    CCDS34.1
    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8, A0A2L0WW42
    Related
    ENSP00000367872.3, ENST00000378609.9
    Conserved Domains (2) summary
    cd00200
    Location:48 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    1785286..1891087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418078.1 → XP_047274034.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    F6X3N5

  2. XM_047418076.1 → XP_047274032.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    F6X3N5
    Related
    ENSP00000515441.1, ENST00000703707.1

  3. XM_017001061.3 → XP_016856550.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8, A0A2L0WW42
    Conserved Domains (2) summary
    cd00200
    Location:48 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]

  4. XM_047418072.1 → XP_047274028.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    F6X3N5
    Related
    ENSP00000399741.3, ENST00000439272.7

  5. XM_017001060.3 → XP_016856549.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8, A0A2L0WW42
    Conserved Domains (2) summary
    cd00200
    Location:48 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]

  6. XM_047418073.1 → XP_047274029.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    F6X3N5

  7. XM_047418070.1 → XP_047274026.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  8. XM_047418049.1 → XP_047274005.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8
    Related
    ENSP00000515440.1, ENST00000703706.1

  9. XM_047418071.1 → XP_047274027.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  10. XM_047418061.1 → XP_047274017.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  11. XM_047418054.1 → XP_047274010.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  12. XM_047418042.1 → XP_047273998.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8
    Related
    ENSP00000515443.1, ENST00000703709.1

  13. XM_047418059.1 → XP_047274015.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  14. XM_047418050.1 → XP_047274006.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  15. XM_047418057.1 → XP_047274013.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  16. XM_047418044.1 → XP_047274000.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  17. XM_047418046.1 → XP_047274002.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  18. XM_047418045.1 → XP_047274001.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  19. XM_024446495.2 → XP_024302263.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8, A0A2L0WW42
    Related
    ENSP00000515434.1, ENST00000703700.1
    Conserved Domains (2) summary
    cd00200
    Location:48 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]

  20. XM_047418058.1 → XP_047274014.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8
    Related
    ENSP00000515428.1, ENST00000703693.1

  21. XM_047418068.1 → XP_047274024.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8
    Related
    ENSP00000515432.1, ENST00000703697.1

  22. XM_047418056.1 → XP_047274012.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8
    Related
    ENSP00000515442.1, ENST00000703708.1

  23. XM_047418074.1 → XP_047274030.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    F6X3N5

  24. XM_047418055.1 → XP_047274011.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  25. XM_047418062.1 → XP_047274018.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  26. XM_047418043.1 → XP_047273999.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8
    Related
    ENSP00000515435.1, ENST00000703701.1

  27. XM_047418069.1 → XP_047274025.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  28. XM_047418063.1 → XP_047274019.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  29. XM_047418060.1 → XP_047274016.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8
    Related
    ENSP00000515438.1, ENST00000703704.1

  30. XM_047418067.1 → XP_047274023.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  31. XM_017001059.3 → XP_016856548.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8, A0A2L0WW42
    Conserved Domains (2) summary
    cd00200
    Location:48 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    1219664..1325475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336086.1 → XP_054192061.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    F6X3N5

  2. XM_054336085.1 → XP_054192060.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    F6X3N5

  3. XM_054336079.1 → XP_054192054.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  4. XM_054336082.1 → XP_054192057.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    F6X3N5

  5. XM_054336073.1 → XP_054192048.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  6. XM_054336083.1 → XP_054192058.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    F6X3N5

  7. XM_054336077.1 → XP_054192052.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  8. XM_054336061.1 → XP_054192036.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  9. XM_054336078.1 → XP_054192053.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  10. XM_054336070.1 → XP_054192045.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  11. XM_054336063.1 → XP_054192038.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  12. XM_054336055.1 → XP_054192030.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  13. XM_054336068.1 → XP_054192043.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  14. XM_054336062.1 → XP_054192037.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  15. XM_054336066.1 → XP_054192041.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  16. XM_054336058.1 → XP_054192033.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  17. XM_054336060.1 → XP_054192035.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  18. XM_054336059.1 → XP_054192034.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  19. XM_054336056.1 → XP_054192031.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  20. XM_054336067.1 → XP_054192042.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  21. XM_054336075.1 → XP_054192050.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  22. XM_054336065.1 → XP_054192040.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  23. XM_054336084.1 → XP_054192059.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    F6X3N5

  24. XM_054336064.1 → XP_054192039.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  25. XM_054336071.1 → XP_054192046.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  26. XM_054336057.1 → XP_054192032.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  27. XM_054336076.1 → XP_054192051.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  28. XM_054336072.1 → XP_054192047.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  29. XM_054336069.1 → XP_054192044.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  30. XM_054336074.1 → XP_054192049.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  31. XM_054336080.1 → XP_054192055.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8

  32. XM_054336081.1 → XP_054192056.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AJZ7, P04697, P04901, P62873, Q1RMY8
    UniProtKB/TrEMBL
    A0A024R056, A0A140VJJ8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62873.3 GenPept UniProtKB/Swiss-Prot:P62873

Gene LinkOut

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