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Imp4 IMP4, U3 small nucleolar ribonucleoprotein [ Mus musculus (house mouse) ]

Gene ID: 27993, updated on 27-Nov-2024

Summary

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Official Symbol
Imp4provided by MGI
Official Full Name
IMP4, U3 small nucleolar ribonucleoproteinprovided by MGI
Primary source
MGI:MGI:106572
See related
Ensembl:ENSMUSG00000026127 AllianceGenome:MGI:106572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1Wsu40e
Summary
Predicted to enable snoRNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit biogenesis. Predicted to be located in fibrillar center. Predicted to be part of Mpp10 complex and small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including axial musculature; extraembryonic component; submandibular gland primordium; thymus primordium; and vibrissa. Orthologous to human IMP4 (IMP U3 small nucleolar ribonucleoprotein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 19.3), ovary adult (RPKM 18.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Imp4 in Genome Data Viewer
Location:
1 B; 1 13.22 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34478951..34488437)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34439829..34445747)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 37233 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:34491786-34491969 Neighboring gene nuclear encoded tRNA glutamic acid 1 (anticodon TTC) Neighboring gene STARR-positive B cell enhancer ABC_E787 Neighboring gene coiled-coil domain containing 115 Neighboring gene predicted gene, 32504 Neighboring gene STARR-positive B cell enhancer mm9_chr1:34519657-34519958 Neighboring gene protein tyrosine phosphatase, non-receptor type 18 Neighboring gene predicted gene 28417

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. Granneman S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655004, Free PMC Article
  2. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables rRNA primary transcript binding IEA
Inferred from Electronic Annotation
more info
  
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Mpp10 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Mpp10 complex ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of preribosome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
U3 small nucleolar ribonucleoprotein protein IMP4
Names
IMP4, U3 small nucleolar ribonucleoprotein, homolog
U3 snoRNP protein 4 homolog
U3 snoRNP protein IMP4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420705.1 → NP_001407634.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC106841

  2. NM_178601.4 → NP_848716.2  U3 small nucleolar ribonucleoprotein protein IMP4 isoform 1

    See identical proteins and their annotated locations for NP_848716.2

    Status: VALIDATED

    Source sequence(s)
    AC106841
    Consensus CDS
    CCDS35536.1
    UniProtKB/Swiss-Prot
    Q3U8H6, Q8CI42, Q8VHZ7, Q9CWN6, Q9CYT5
    Related
    ENSMUSP00000027303.8, ENSMUST00000027303.14
    Conserved Domains (1) summary
    smart00879
    Location:86 → 253
    Brix; The Brix domain is found in a number of eukaryotic proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    34478951..34488437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHZ7.1 GenPept UniProtKB/Swiss-Prot:Q8VHZ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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