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Miip migration and invasion inhibitory protein [ Mus musculus (house mouse) ]

Gene ID: 28010, updated on 27-Nov-2024

Summary

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Official Symbol
Miipprovided by MGI
Official Full Name
migration and invasion inhibitory proteinprovided by MGI
Primary source
MGI:MGI:106506
See related
Ensembl:ENSMUSG00000029022 AllianceGenome:MGI:106506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IIP45; D4Wsu114e
Summary
Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of cell migration. Is expressed in embryo. Orthologous to human MIIP (migration and invasion inhibitory protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 32.0), thymus adult (RPKM 28.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Miip in Genome Data Viewer
Location:
4 E1; 4 78.56 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (147945235..147953176, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (147860778..147868719, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:147131061-147131362 Neighboring gene STARR-positive B cell enhancer mm9_chr4:147137358-147137659 Neighboring gene zinc finger protein 984 Neighboring gene STARR-positive B cell enhancer mm9_chr4:147149499-147149800 Neighboring gene STARR-positive B cell enhancer mm9_chr4:147153946-147154247 Neighboring gene STARR-positive B cell enhancer ABC_E4724 Neighboring gene STARR-positive B cell enhancer ABC_E9623 Neighboring gene STARR-positive B cell enhancer ABC_E6282 Neighboring gene STARR-seq mESC enhancer starr_12061 Neighboring gene STARR-positive B cell enhancer mm9_chr4:147185666-147185967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:147187429-147187616 Neighboring gene STARR-positive B cell enhancer mm9_chr4:147188614-147188915 Neighboring gene ribosomal protein S19, pseudogene 3 Neighboring gene zinc finger protein 933 Neighboring gene STARR-positive B cell enhancer ABC_E4726 Neighboring gene STARR-positive B cell enhancer ABC_E181 Neighboring gene Friend virus susceptibility 1 Neighboring gene mitofusin 2 Neighboring gene STARR-positive B cell enhancer ABC_E9625

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. Strong ER, et al. Genes (Basel), 2010 Dec 2. PMID 21779533, Free PMC Article
  2. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
migration and invasion-inhibitory protein
Names
invasion inhibitory protein 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025365.2 → NP_001020536.2  migration and invasion-inhibitory protein isoform 2

    See identical proteins and their annotated locations for NP_001020536.2

    Status: VALIDATED

    Source sequence(s)
    CO039431, FJ618908
    Consensus CDS
    CCDS18923.2
    UniProtKB/Swiss-Prot
    A2A7Y5, Q3UZ92, Q8CFZ8, Q8VD71
    UniProtKB/TrEMBL
    C0KL25
    Related
    ENSMUSP00000030886.9, ENSMUST00000030886.15
    Conserved Domains (1) summary
    pfam15734
    Location:42 → 379
    MIIP; Migration and invasion-inhibitory

  2. NM_001374704.1 → NP_001361633.1  migration and invasion-inhibitory protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL607066
    Consensus CDS
    CCDS89855.1
    Conserved Domains (1) summary
    pfam15734
    Location:42 → 362
    MIIP; Migration and invasion-inhibitory

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    147945235..147953176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164176.1 → XP_036020069.1  migration and invasion-inhibitory protein isoform X2

    UniProtKB/Swiss-Prot
    A2A7Y5, Q3UZ92, Q8CFZ8, Q8VD71
    UniProtKB/TrEMBL
    C0KL25
    Conserved Domains (1) summary
    pfam15734
    Location:42 → 379
    MIIP; Migration and invasion-inhibitory

  2. XM_006538951.5 → XP_006539014.1  migration and invasion-inhibitory protein isoform X3

    Conserved Domains (1) summary
    pfam15734
    Location:1 → 310
    MIIP; Migration and invasion-inhibitory

  3. XM_036164177.1 → XP_036020070.1  migration and invasion-inhibitory protein isoform X4

    Conserved Domains (1) summary
    pfam15734
    Location:1 → 327
    MIIP; Migration and invasion-inhibitory

  4. XM_036164175.1 → XP_036020068.1  migration and invasion-inhibitory protein isoform X1

    Related
    ENSMUSP00000113897.3, ENSMUST00000119975.3
    Conserved Domains (1) summary
    pfam15734
    Location:42 → 362
    MIIP; Migration and invasion-inhibitory

RNA

  1. XR_004941917.1 RNA Sequence

  2. XR_001784152.3 RNA Sequence

  3. XR_004941916.1 RNA Sequence

    Related
    ENSMUST00000156374.9

  4. XR_004941918.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133873.2: Suppressed sequence

    Description
    NM_133873.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A7Y5.1 GenPept UniProtKB/Swiss-Prot:A2A7Y5

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