DBH dopamine beta-hydroxylase [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: DBHprovided by VGNC
Official Full Name: dopamine beta-hydroxylaseprovided by VGNC
Primary source: VGNC:VGNC:27888
See related: BGD:BT11121; Ensembl:ENSBTAG00000004508
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	11	NC_037338.1 (104498728..104516525)

Chromosome 11 - NC_037338.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The present study presents evidence for the conclusion that the catalytic activity of dopamine beta-hydroxylase (DBH; dopamine beta-mono-oxygenase, EC 1.14.17.1) is regulated independently by pH and by anions
Title: Anion- and pH-dependent activation of the soluble form of dopamine beta-hydroxylase.
dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase
Title: Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DBH (e-PCR), detects polymorphism
- UniSTS:506142

DBH (e-PCR), detects polymorphism
- UniSTS:251724

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables dopamine beta-monooxygenase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in dopamine catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in norepinephrine biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in octopamine biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in secretory granule membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dopamine beta-hydroxylase

Names: dopamine beta-monooxygenase

NP_851338.2

EC 1.14.17.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.