LUM lumican [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: LUMprovided by VGNC
Official Full Name: lumicanprovided by VGNC
Primary source: VGNC:VGNC:31081
See related: BGD:BT23729; Ensembl:ENSBTAG00000001745
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	5	NC_037332.1 (20971292..20981075, complement)

Chromosome 5 - NC_037332.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that lumican plays a pivotal role in the development of tissue engineered cartilage and that regulation of this protein may be important for the production of high-quality implants.
Title: Lumican inhibits collagen deposition in tissue engineered cartilage.

Submit: New GeneRIF Correction

General gene information

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Markers

RME09 (e-PCR)
- UniSTS:251491

MARC_12451-12452:997211314:1 (e-PCR)
- UniSTS:267424

MARC_12451-12452:999282107:3 (e-PCR)
- UniSTS:267424

MARC_12453-12454:997214178:1 (e-PCR)
- UniSTS:267425

LUM (e-PCR)
- UniSTS:278702

CSAP19E (e-PCR), detects polymorphism
- UniSTS:279490

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables collagen binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: lumican

Names: KSPG; corneal keratan sulfate proteoglycan 37B core protein; keratan sulfate proteoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173934.1 → NP_776359.1 lumican precursor

See identical proteins and their annotated locations for NP_776359.1

Status: PROVISIONAL

Source sequence(s)

L11063

UniProtKB/Swiss-Prot

Q05443, Q3T0T2

UniProtKB/TrEMBL

A0AAA9S270

Related

ENSBTAP00070048221.1, ENSBTAT00070079496.1

Conserved Domains (4) summary

smart00013
Location:41 → 75

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:70 → 271

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:72 → 95

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:70 → 132

LRR_8; Leucine rich repeat