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PAM peptidylglycine alpha-amidating monooxygenase [ Bos taurus (domestic cattle) ]

Gene ID: 280890, updated on 29-Jan-2025

Summary

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Official Symbol
PAMprovided by VGNC
Official Full Name
peptidylglycine alpha-amidating monooxygenaseprovided by VGNC
Primary source
VGNC:VGNC:32561
See related
BGD:BT18853; Ensembl:ENSBTAG00000012387
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See PAM in Genome Data Viewer
Location:
chromosome: 7
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (101750589..102084447)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL30-like Neighboring gene uncharacterized LOC132345842 Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene large ribosomal subunit protein uL18-like Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene diphosphoinositol pentakisphosphate kinase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Structure of the precursor to an enzyme mediating COOH-terminal amidation in peptide biosynthesis. Eipper BA, et al. Mol Endocrinol, 1987 Nov. PMID 3153462
  2. Functional and structural characterization of peptidylamidoglycolate lyase, the enzyme catalyzing the second step in peptide amidation. Katopodis AG, et al. Biochemistry, 1991 Jun 25. PMID 2059626
  3. Effect of cortisol on neurophysin I/oxytocin and peptidyl glycine-alpha-amidating mono-oxygenase mRNA expression in bovine luteal and granulosa cells. Ziolkowska A, et al. Pol J Vet Sci, 2013. PMID 23971190
  4. Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue. Li Q, et al. J Anim Sci, 2019 Feb 1. PMID 30476104, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data suggest that cortisol affects oxytocin synthesis and secretion in bovine ovarian cells, by acting on the expression of key genes, that may impair ovary
    Title: Effect of cortisol on neurophysin I/oxytocin and peptidyl glycine-alpha-amidating mono-oxygenase mRNA expression in bovine luteal and granulosa cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC137729

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptidylglycine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptide metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
peptidyl-glycine alpha-amidating monooxygenase
NP_776373.1
XP_005209819.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173948.2 → NP_776373.1  peptidyl-glycine alpha-amidating monooxygenase precursor

    See identical proteins and their annotated locations for NP_776373.1

    Status: PROVISIONAL

    Source sequence(s)
    M18683
    UniProtKB/Swiss-Prot
    P10731
    UniProtKB/TrEMBL
    A0A3Q1MT65
    Related
    ENSBTAP00070000773.1, ENSBTAT00070001099.1
    Conserved Domains (4) summary
    COG3391
    Location:557 → 824
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd14958
    Location:500 → 807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59 → 168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196 → 342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    101750589..102084447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005209762.5 → XP_005209819.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

    See identical proteins and their annotated locations for XP_005209819.1

    UniProtKB/TrEMBL
    A0A3Q1MT65
    Conserved Domains (4) summary
    COG3391
    Location:557 → 824
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd14958
    Location:500 → 807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59 → 168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196 → 342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10731.2 GenPept UniProtKB/Swiss-Prot:P10731

Gene LinkOut

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Molecular Biology Databases
Research Materials