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ACO2 aconitase 2 [ Bos taurus (domestic cattle) ]

Gene ID: 280976, updated on 27-Dec-2024

Summary

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Official Symbol
ACO2provided by VGNC
Official Full Name
aconitase 2provided by VGNC
Primary source
VGNC:VGNC:25546
See related
BGD:BT23912; Ensembl:ENSBTAG00000006429
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See ACO2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (112568137..112617201)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene transducer of ERBB2, 2 Neighboring gene PHD finger protein 5A Neighboring gene uncharacterized LOC112446877 Neighboring gene RNA polymerase III subunit H Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene cold shock domain containing C2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Identification of the reactive sulfhydryl and sequences of cysteinyl-tryptic peptides from beef heart aconitase. Plank DW, et al. J Biol Chem, 1988 Jun 15. PMID 3372519
  2. Cysteine labeling studies of beef heart aconitase containing a 4Fe, a cubane 3Fe, or a linear 3Fe cluster. Plank DW, et al. J Biol Chem, 1989 Dec 5. PMID 2511202
  3. Crystal structures of aconitase with isocitrate and nitroisocitrate bound. Lauble H, et al. Biochemistry, 1992 Mar 17. PMID 1547214
  4. Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein. Kennedy MC, et al. Proc Natl Acad Sci U S A, 1992 Dec 15. PMID 1334546, Free PMC Article
  5. Isolation of coding sequences from bovine cosmids by means of exon trapping. Comincini S, et al. Mamm Genome, 1997 Jul. PMID 9195992

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables aconitate hydratase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
aconitate hydratase, mitochondrial
Names
aconitase 2, mitochondrial
citrate hydro-lyase
NP_776402.1
XP_059742072.1
XP_059742073.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173977.3 → NP_776402.1  aconitate hydratase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_776402.1

    Status: PROVISIONAL

    Source sequence(s)
    Z49931
    UniProtKB/TrEMBL
    A0AAF6YQ44
    Related
    ENSBTAP00000078293.1, ENSBTAT00000126438.1
    Conserved Domains (3) summary
    cd01584
    Location:95 → 505
    AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
    cd01578
    Location:587 → 735
    AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
    TIGR01340
    Location:45 → 775
    aconitase_mito; aconitate hydratase, mitochondrial

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    112568137..112617201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059886089.1 → XP_059742072.1  aconitate hydratase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q1P9Q3

  2. XM_059886090.1 → XP_059742073.1  aconitate hydratase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q1P9Q3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20004.4 GenPept UniProtKB/Swiss-Prot:P20004

Gene LinkOut

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