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AGRP agouti related neuropeptide [ Bos taurus (domestic cattle) ]

Gene ID: 280987, updated on 29-Jan-2025

Summary

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Official Symbol
AGRPprovided by VGNC
Official Full Name
agouti related neuropeptideprovided by VGNC
Primary source
VGNC:VGNC:25743
See related
BGD:BT11339; Ensembl:ENSBTAG00000014556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See AGRP in Genome Data Viewer
Location:
chromosome: 18
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (35086439..35087189, complement)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 11-beta dehydrogenase 2 Neighboring gene ATPase H+ transporting V0 subunit d1 Neighboring gene uncharacterized LOC101906364 Neighboring gene RHO family interacting cell polarization regulator 1 Neighboring gene uncharacterized LOC132342823 Neighboring gene CCCTC-binding factor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Sustained inhibitory effect of Agouti Related Protein on the ACTH-induced cortisol production by bovine cultured adrenal cells. Doghman M, et al. Regul Pept, 2005 Jan 15. PMID 15544862
  2. Agouti-related protein antagonizes glucocorticoid production induced through melanocortin 4 receptor activation in bovine adrenal cells: a possible autocrine control. Doghman M, et al. Endocrinology, 2004 Feb. PMID 14592963
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. (Nle4, d-Phe7)-alphaMSH (NDP-alphaMSH) stimulated the production of cortisol and these effects were abolished by agouti related protein or SHU9119, a synthetic antagonist of melanocortin 3 and melanocortin 4 receptor
    Title: Agouti-related protein antagonizes glucocorticoid production induced through melanocortin 4 receptor activation in bovine adrenal cells: a possible autocrine control.
  2. Agrp inhibited, in a dose-dependent manner, the 10(-9) M NDP-alphaMSH-induced cortisol production through its antagonistic properties towards MSH at the level of MC4-R
    Title: Sustained inhibitory effect of Agouti Related Protein on the ACTH-induced cortisol production by bovine cultured adrenal cells.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables type 1 melanocortin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult feeding behavior IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
agouti-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173983.2 → NP_776408.2  agouti-related protein precursor

    Status: VALIDATED

    Source sequence(s)
    NKLS02000018
    UniProtKB/Swiss-Prot
    P56413
    UniProtKB/TrEMBL
    D2CNK1
    Related
    ENSBTAP00070009021.1, ENSBTAT00070015861.1
    Conserved Domains (1) summary
    smart00792
    Location:1 → 124
    Agouti; Agouti protein

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    35086439..35087189 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001171546.1: Suppressed sequence

    Description
    NM_001171546.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56413.1 GenPept UniProtKB/Swiss-Prot:P56413

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials