BCL2 BCL2 apoptosis regulator [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: BCL2provided by VGNC
Official Full Name: BCL2 apoptosis regulatorprovided by VGNC
Primary source: VGNC:VGNC:26445
See related: BGD:BT11029; Ensembl:ENSBTAG00000019302
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	24	NC_037351.1 (61396513..61589028, complement)

Chromosome 24 - NC_037351.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Over-expression of STC-1 up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism.
Title: Stanniocalcin-1 protects bovine intestinal epithelial cells from oxidative stress-induced damage.
BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax expression.
Title: Bovine herpesvirus type 5 infection regulates Bax/BCL-2 ratio.
These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.
Title: Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2.
mRNA expression of Bax, Bcl-2, caspase-3 and-7 cannot be used as a reliable apoptosis detection method.
Title: mRNA expression of Bcl-2, Bax, caspase-3 and -7 cannot be used as a marker for apoptosis in bovine blastocysts.
G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.
Title: BCL-2 antisense oligonucleotide genasense is active against imatinib-resistant BCR-ABL-positive cells.
role of vascular endothelial growth factor receptor-1 in Bcl-2 expression
Title: Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells.
apoptosis-inducing factor was expressed in luminal alveolar cells and, in concert with a change in bax protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
Title: Functional expression of bcl-2 protein family and AIF in bovine mammary tissue in early lactation.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: apoptosis regulator Bcl-2

Names: B-cell CLL/lymphoma 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166486.1 → NP_001159958.1 apoptosis regulator Bcl-2

See identical proteins and their annotated locations for NP_001159958.1

Status: PROVISIONAL

Source sequence(s)

NKLS02000024

UniProtKB/Swiss-Prot

O02718

UniProtKB/TrEMBL

F6R2C4

Related

ENSBTAP00000025701.5, ENSBTAT00000025701.7

Conserved Domains (1) summary

TIGR00865
Location:1 → 229

bcl-2; apoptosis regulator

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

Range

61396513..61589028 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005224105.5 → XP_005224162.1 apoptosis regulator Bcl-2 isoform X1

UniProtKB/TrEMBL

Q8MJ81

Conserved Domains (3) summary

smart00265
Location:7 → 30

BH4; BH4 Bcl-2 homology region 4

cd06845
Location:84 → 185

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:1 → 185

bcl-2; apoptosis regulator
XM_024984176.2 → XP_024839944.1 apoptosis regulator Bcl-2 isoform X2

UniProtKB/TrEMBL

Q8MJ81

Conserved Domains (1) summary

TIGR00865
Location:1 → 185

bcl-2; apoptosis regulator