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CLTC clathrin heavy chain [ Bos taurus (domestic cattle) ]

Gene ID: 281080, updated on 27-Dec-2024

Summary

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Official Symbol
CLTCprovided by VGNC
Official Full Name
clathrin heavy chainprovided by VGNC
Primary source
VGNC:VGNC:27471
See related
Ensembl:ENSBTAG00000016708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See CLTC in Genome Data Viewer
Location:
chromosome: 19
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (10595559..10665492)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343002 Neighboring gene DEAH-box helicase 40 Neighboring gene peptidyl-tRNA hydrolase 2 Neighboring gene vacuole membrane protein 1 Neighboring gene microRNA mir-21

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Entry of bovine parainfluenza virus type 3 into MDBK cells occurs via clathrin-mediated endocytosis and macropinocytosis in a acid-dependent manner. Pan W, et al. Vet Microbiol, 2021 Aug. PMID 34147763
  2. Nuclear Magnetic Resonance Structural Mapping Reveals Promiscuous Interactions between Clathrin-Box Motif Sequences and the N-Terminal Domain of the Clathrin Heavy Chain. Zhuo Y, et al. Biochemistry, 2015 Apr 28. PMID 25844500, Free PMC Article
  3. AFM visualization of clathrin triskelia under fluid and in air. Kotova S, et al. FEBS Lett, 2010 Jan 4. PMID 19925798, Free PMC Article
  4. Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs. Liu SH, et al. Cell, 1995 Oct 20. PMID 7585943
  5. Two Distantly Spaced Basic Patches in the Flexible Domain of Huntingtin-Interacting Protein 1 (HIP1) Are Essential for the Binding of Clathrin Light Chain. Ybe JA, et al. Res Lett Biochem, 2009. PMID 22820750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Entry of bovine parainfluenza virus type 3 into MDBK cells occurs via clathrin-mediated endocytosis and macropinocytosis in a acid-dependent manner.
    Title: Entry of bovine parainfluenza virus type 3 into MDBK cells occurs via clathrin-mediated endocytosis and macropinocytosis in a acid-dependent manner.
  2. three different clathrin-box motif peptides can each simultaneously bind not only to the previously characterized clathrin-box site but also to the W-box site and the beta-arrestin splice loop site on a single TD.
    Title: Nuclear Magnetic Resonance Structural Mapping Reveals Promiscuous Interactions between Clathrin-Box Motif Sequences and the N-Terminal Domain of the Clathrin Heavy Chain.
  3. Structure of clathrin coat with bound Hsc70 and auxilin.
    Title: Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.
  4. clathrin-FKBP36-Hsp72 complexes resulting from both identified interactions are bound to the matrices of clathrin-coated vesicles in spermatocytes, which indicates a possible role of FKBP36 and Hsp72 in the disassembly of clathrin coats
    Title: FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables clathrin light chain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of clathrin coat of coated pit IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of clathrin coat of trans-Golgi network vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of clathrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in clathrin-coated endocytic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular exosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
clathrin heavy chain 1
Names
clathrin, heavy chain (Hc)
clathrin, heavy polypeptide (Hc)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174023.2 → NP_776448.1  clathrin heavy chain 1

    Status: PROVISIONAL

    Source sequence(s)
    U31757
    UniProtKB/Swiss-Prot
    P49951
    UniProtKB/TrEMBL
    A0AAA9RYT0
    Related
    ENSBTAP00000076444.1, ENSBTAT00000130861.1
    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam00637
    Location:979 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    10595559..10665492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024979563.2 → XP_024835331.1  clathrin heavy chain 1 isoform X2

    UniProtKB/TrEMBL
    A0AAA9RYT0
    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam00637
    Location:1427 → 1561
    Clathrin; Region in Clathrin and VPS
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link

  2. XM_024979562.2 → XP_024835330.1  clathrin heavy chain 1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9RYT0, A0AAA9SF14
    Related
    ENSBTAP00000082194.1, ENSBTAT00000114042.1
    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam00637
    Location:979 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49951.1 GenPept UniProtKB/Swiss-Prot:P49951

Gene LinkOut

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